Fluorous separations

Fluorous chemistry evolved from groundbreaking research by Horváth and Curran in fluorous liquid-liquid and solid-phase separation protocols, respectively.  Originally intended as a tool for organic synthesis, the technology took advantage of the orthogonality of the fluorous phase. Numerous tools and protocols were developed for molecular tagging and scavenging, and demonstration of the chemistry evolved in medicinal chemistry, biochemistry, and other areas.

Among the tools developed were solid-phase separation formats and protocols, including HPLC and flash chromatography (solid phase extraction).  Based on FluoroFlash® silica gel, these products have subsequently found utility in other areas like separation of lightly-fluorinated molecules as well as applications related to the nationwide challenge of perfluoroalkylated substances (PFAS) in the environment - the legacy of activities like production of polytetrafluoroethylene and the use of fluorinated firefighting foams like AFFF.



Fluorous Technologies is a unit of Boron Specialties, LLC, 2301 Duss Avenue Suite 35, Ambridge, PA 15003

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Separate Molecules with Simple Protocols

Chemical separations are at the heart of the Fluorous Technology platform. With simple protocols for the separation of fluorous molecules from non-fluorous molecules using fluorous solid phase extraction (FSPE) or fluorous liquid-liquid extraction (FLLE), we're sure that you'll agree that it's easy to purify reaction mixtures with Fluorous. Fluorous HPLC offers the greatest resolving power.


Selective Partioning into the Orthogonal Fluorous Phase

The basis of fluorous separations is the orthogonal nature of the fluorous phase. Fluorous molecules are both hydrophobic and lipophobic and selectively partition into a fluorous phase. This can be a solid, like FluoroFlash silica gel, or a fluorous solvent.


Purify Synthetic Reaction Mixtures and Enrich Complex Biological Samples

With fluorous separations you can easily purify small molecule libraries, remove unwanted deletion sequences, and enrich complex biological samples for targeted molecules.