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All Trial, No Error. The Fluorous Trial Kit Offer

To help you explore how fluorous chemistry can save you valuable time and money, we are making you a special, limited time offer: Try one of our fluorous trial kits tailored specifically to your chemistry needs. Pick any two or three of our FluoroFlash™ products and we'll package it with two 2 gram F-SPE Cartridges. So whether you are looking to purify a Mitsunobu reaction or try some innovative solution phase scavenging, we have a kit for you. Learn more about our trial kits...

Fluorous Chemistry at the National Organic Symposium, June 8-12

Fluorous Technologies will be presenting three new posters at the upcoming National Organic Symposium in Bloomington, IN. The posters will be presented during the June 10th poster session. Each poster highlights recent advancements made by FTI scientists: Solution-Phase Libraries by Fluorous Parallel Synthesis, Solution-Phase Libraries by Fluorous Mixture Synthesis, and New Developments in Fluorous Mitsunobu Reactions.

Amino Acids added to the FluoroFlash™ Product Line

Be sure to watch for our next web catalog release, when we will be offering 32 exciting new products: fluorous Cbz-protected amino acids. The L and D enantiomers of each amino acid will be protected by different length fluorous tags, allowing for fluorous quasiracemic synthesis. The utility of these products has previously been demonstrated by van Boom and Curran. To begin your fluorous peptide synthesis today, please contact us.

The Latest Innovative Publications from FTI Scientists

In published work entitled "FluoMar™, a Fluorous Version of the Marshall Resin for Solution-Phase Library Synthesis" (Organic Letters, 2003, 5, 1015), Christine Chen and Wei Zhang of FTI reported the development of a fluorous alternative to the Marshall resin and its application in solution-phase parallel synthesis of a diamide library. Compared to the Marshall resin, FluoMar™ has the advantage of solution-phase reactivity such as faster reaction, convenient intermediate analysis and straightforward purification.

The same issue of Organic Letters also contains a paper entitled "Fluorous Synthesis of Disubstituted Pyrimidines" (Organic Letters 2003, 5, 1011).

In it, Wei Zhang from FTI reports the application of fluorous thiol as a traceless tag in the synthesis of disubstituted pyrimidines. In this work, a dichloropyrimidine was attached to the fluorous thiol and the tagged species was taken through a sequence of pyrazole substitution, sulfide oxidation, and fluorous tag displacement by nucleophiles. This technology can be applied to the synthesis of other substituted N-heterocyles such as quinazolines and purines.

Other recent publications from the staff at Fluorous Technologies include a review of Fluorous Mixture Synthesis and a report in Tetrahedron Letters describing the utility of fluorous scavengers (right) in targeted library synthesis.

Fluorous Biphasic Catalysis without Fluorous Solvents

Two recent reports have extended fluorous biphasic catalysis from the liquid-liquid domain to the solid-liquid domain there by eliminating the need for fluorous solvents altogether. Wende and Gladysz reported a fluorous phosphine catalyzed Michael addition reaction where n-octane is the only solvent used, while Bannwarth et al [1] described fluorous Pd catalyst supported on fluorous silica for Suzuki and Sonagashira reactions. Both examples are characterized by high catalyst recovery and the ability to recycle the catalyst over several cycles. These references highlight an exciting direction in fluorous biphasic catalysis that obviates the need for fluorous solvents. Fluorous Technologies, Inc. provides a complete array of products and services to meet your process chemistry needs including FluoroFlash™ silica gel, fluorous phosphines, fluorous catalysts as well as world-class technical support. Contact us today to discuss how we can help!

[1] Carl Christoph Tzschucke, Christian Markert, Heiko Glatz, Willi Bannwarth* "Fluorous Biphasic Catalysis without Perfluorinated Solvents: Application to Pd-Mediated Suzuki and Sonogashira Couplings" Angew. Chem. Int. Ed. 2002, 41, No. 23, 4500-4503

Fluorous Technologies, Inc. (FTI) is a chemical technology company dedicated to the development and commercialization of fluorous products focused at the life science market. The company uses patented technology to solve synthesis and separation problems spanning the entire drug discovery and development process. FTI further leverages its enabling technology through service contracts, licenses, and collaborations.

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