If your email does not support graphics, access the web version of this newsletter.

Fluorous Technologies, Inc. (FTI) is a chemical technology company dedicated to the development and commercialization of fluorous products focused at the life science market. The company uses patented technology to solve synthesis and separation problems spanning the entire drug discovery and development process. FTI further leverages its enabling technology through service contracts, licenses, and collaborations.

Fluorous Microwave Palladium Coupling

FTI scientists have shown that the combination of a microwave accelerated reaction with a fluorous facilitated separation can dramatically increase the efficiency of high-speed organic synthesis. Palladium-catalyzed cross-coupling reaction of aryl perfluoroalkylsulfonates (C8F17O2SOAr) and thiols (RSH) under microwave irradiation afforded aryl sulfides which were purified by fluorous solid-phase extraction (F-SPE). No fluorous solvents are involved in the reaction and separation process. This method of fluorous synthesis has been further extended to multi-step syntheses of substituted hydantoin and amide scaffolds.  FTI now offers the Pd(dppf)Cl2 reagent used below in a fluorous form.   To see pricing information, please click here.

Scheme 1 . Microwave –assisted fluorous synthesis of aryl sulfides

Scheme 2. F-Sulfonate-tagged multi-step synthesis of substituted hydantoin

Zhang, W. et al, Molecular Diversity, 2003, 7, 199-202. [Abstract, PDF after login]

Suggest a New Product,  Receive a Free Sample

As part of our commitment to be the leader in fluorous innovation, we are currently looking for new product ideas.  If your new product suggestion becomes a commercial product, we will send you up to 10g free*.  Please click here to submit your idea.  To see our latest innovations, please visit our product development page.

* Actual amount dependent on specific product.

FTI at CHI's High-Throughput Purification Forum on Feb. 26, 2004

Prof. Dennis Curran, founder of Fluorous Technologies, will be the keynote speaker at CHI's one-day High-Throughput Purification Forum.  This forum will follow the three day Advancing Library Design and Organic Synthesis Conference In La Jolla, CA from Feb. 23-25th, 2004.

As a guest of Fluorous Technologies, you are entitled to a $100 discount on a commercial registration and $50 discount on an academic registration!  To register, click here (please note: you must use this link to receive the discount if registering on-line ) or call Cambridge Healthtech Institute directly at 617-630-1300 and ask for Registration.  Be sure to mention your priority code: LDSFL in order to receive your discount.

FTI's Product Selection Chart for Aniline, Ester, and Ether Chemistry

In an effort to make your fluorous product selection easier, FTI has released a product selection tool for Aniline, Ester, and Ether chemistry. We also recently released a similar tool for amine and amide chemistry.  If you have specific product questions, please contact Kris Mikulan, our technical support specialist by clicking here.

Cutting Edge Fluorous Chemistry

Fluorous Technologies, Inc. (FTI) is a chemical technology company dedicated to the development and commercialization of fluorous products focused at the life science market. The company uses patented technology to solve synthesis and separation problems spanning the entire drug discovery and development process. FTI further leverages its enabling technology through service contracts, licenses, and collaborations.

For further information please contact FTI at 412-826-3050. We value your privacy. To learn more about how FTI uses personal information, consult our privacy policy. To unsubscribe from this newsletter, please reply to this email with "unsubscribe" in the subject line.

FluoroFlash® is a registered trademark of Fluorous Technologies, Inc.