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Innovators Wanted

We are currently looking for innovative thinkers to evaluate our technology. After trying fluorous chemistry in an agreed upon lab plan, the testimonials and publishable data you create will be used in a white paper. As a program participant, you will interact directly with company founder Professor Dennis P. Curran to design and execute the experiments. Innovative thinkers apply here.


 

FTI, Mettler Toledo, & CEM Hold Tri-Seminar on October 2nd

Please join us for presentations by leading chemists from Aventis, Merck, and Boston University. Learn how they have combined new methods and technologies to create an integrated solution for increasing lead generation and optimization of drug candidates. A discussion will follow on how these new technologies can be combined into a powerful suite of tools for unlocking the full potential of your drug development program. To learn more or to register, please click here.


 

Get to Know Fluorous Chemistry: Literature Highlights

General Reviews:

W. Zhang, "Fluorous Technologies for Solution-Phase High-Throughput Organic Synthesis" Tetrahedron Report Tetrahedron 2003, 59:25:4475-4489 [Abstract]

D. P. Curran and Co-workers, "Fluorous Synthesis: A User's Guide", In Combinatorial Chemistry: A Practical Approach; H. Fenniri, Ed.; Oxford Univ Press: Oxford, 2000; Vol. 2; pp 327-352

Specific Applications:

S. Dandapani, D. P. Curran, "Fluorous Mitsunobu reagents and reactions" Tetrahedron 2002, 58, 3855-64. [Full Article]

C. Lindsley, Z. Zhao & W.Leister of Merck West Point, "Fluorous-Tethered Quenching Reagents for Solution Phase Parallel Synthesis" Tetrahedron Letters 2002 , 43:23:4225 - 4228 [Abstract]

W. Zhang, "Fluorous synthesis of Disubstituted Pyrimidines", Org. Lett. 2003, 5, 1011-13. [Full Article]

J. H. van Boom and Co-workers, "Use of Benzyloxycarbonyl (Z)-Based Fluorophilic Tagging Reagents in the Purification of Synthetic Peptides." Tetrahedron Letters, 21 October 2002, Volume 43, Issue 43, Pages 7809-7812 [Full Article]

D. P. Curran and Co-workers, "Synthesis and Reactions of Fluorous Carbobenzyloxy (fCbz) Derivatives of a-Amino Acids" Journal of Organic Chemistry 2003, 68, 4643-4647 [Full Article]

D. P. Curran, "Fluorous Reverse Phase Silica Gel. A New Tool for Preparative Separations in
Synthetic Organic and Organofluorine Chemistry" Synlett 2001, 1488-1496. [Full Article]

W. Zhang, Z. Luo, C. H.-T. Chen, D. P. Curran "Solution-Phase Preparation of a 560-Compound Library of Individually Pure Mappicine Analogs by Fluorous Mixture Synthesis" J. Am. Chem. Soc., 2002, 124, 10443. [Full Article]

D. P. Curran and Co-workers, "Resolution of 1-(2-Naphthyl)ethanol by a Combination of an enzyme-catalyzed kinetic resolution with a fluorous triphasic separative reaction", Org. Lett. 2002, 4, 2585. [Full Article]


 

Fluorous Newsletter Highlights

July 2003 Newsletter
Topics: F-Tagged Amino Acids for Peptide Synthesis, Fluorous reagents in Isotope Separations, New Application Notes

May 2003 Newsletter
Topics: Our latest Drug Discovery Publications, Fluorous Biphasic Catalysis

March 2003 Newsletter
Topics: Fluorous sorbents in Biotage format, Fluorous microwave reactions

February 2003 Newsletter
Topics: Fluorous Reviews, Fluorous Biphasic Esterification


Fluorous Technologies, Inc. (FTI) is a chemical technology company dedicated to the development and commercialization of fluorous products focused at the life science market. The company uses patented technology to solve synthesis and separation problems spanning the entire drug discovery and development process. FTI further leverages its enabling technology through service contracts, licenses, and collaborations.

For further information please contact FTI at 412-826-3050. We value your privacy. To learn more about how FTI uses personal information, consult our privacy policy. To unsubscribe from this newsletter, please reply to this email with "unsubscribe" in the subject line.

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