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FTI, Mettler Toledo, & CEM to Hold Seminar on October 2nd

Please join us for presentations by leading chemists from Aventis, Merck, and Boston University. Learn how fluorous chemistry, automated parallel synthesis, and microwave synthesis can be combined to create an integrated solution for increasing lead generation and optimization of drug candidates. A discussion will follow on how these new technologies can be combined into a powerful suite of tools for unlocking the full potential of your drug development program. To learn more or to register, please click here.

FTI Releases New Catalog of FluoroFlash® Products

FTI is pleased to announce its release of a new product catalog. Innovative products added to this catalog are: fluorous tagged amino acids for peptide synthesis, the F-DAIB reagent, and F-Salen Cobalt catalyst for use as an epoxidation reagent. Download the catalog or register to receive a CD-ROM version.

Fluorous Traceless Tag for Heterocyclic Synthesis

In a recent article published in Organic Letters (2003, 5(14), 2555), Wei Zhang, head of combinatory chemistry and Yimin Lu of FTI introduced a fluorous traceless tag for parallel synthesis of hydantoins and thiohydantoins. Fluorous-tagged amino estesrs were used as starting material to react with aldehydes under reductive amination conditions. The intermediate was then reacted with isocyanates to form ureas which underwent simultaneous cyclizations to form hydantoin analogs. Both intermediate and product were isolated in high yield and purity after solid-phase extraction over FluoroFlash® cartridges. This chemistry demonstrated that the in solution-phase synthesis, fluorous tags can be used in a similar way as polymeric linkers in solid-phase synthesis to provide a high purity product with easy separations.

Fluorous Chiral Auxiliary

Professor Philip Hultin at the University of Manitoba recently reported the use a fluorous version of the classic Evans auxiliary in Ti-mediated aldol reactions.1 As seen below, the reactions provided high d.r. and e.e. in reactions with benzaldehyde and alkanals. All products were purified by fluorous solid phase extraction (F-SPE). The configuration, selectivity, and yield of products were consistent with those reported for non-fluorous oxazolidinone auxiliaries. The fluorous chiral auxiliary not only transfers chirality, but also provides a method to quickly isolate the products.

Professor Hultin's work is an excellent example of how traditional synthetic methods can be rendered fluorous and the wide range of chemical compatibility of fluorous methods. The original solution phase behavior is retained while providing easier purification.

1. Hein, J.E.; Hultin, P.G. Synlett, 2003, 5, 635.

FTI adds Technical Support Specialist

FTI is committed to providing unparalleled customer support to our growing customer base. To that end, Kris Mikulan has joined the Fluorous team as a Technical Support Specialist. She can be reached via email or phone at 412-826-3043. As always, we appreciate your business!

Fluorous Technologies, Inc. (FTI) is a chemical technology company dedicated to the development and commercialization of fluorous products focused at the life science market. The company uses patented technology to solve synthesis and separation problems spanning the entire drug discovery and development process. FTI further leverages its enabling technology through service contracts, licenses, and collaborations.

For further information please contact FTI at 412-826-3050. We value your privacy. To learn more about how FTI uses personal information, consult our privacy policy. To unsubscribe from this newsletter, please reply to this email with "unsubscribe" in the subject line.

FluoroFlash® is a registered trademark of Fluorous Technologies, Inc.