Tag Archives: Zhang

Isotope-coded Fluorous PALs

Prof. Qisheng Zhang at UNC-Chapel Hill has published several papers about the synthesis and use of fluorous tagged photoaffinity labels (PALs) and has just published another report in Chemical Communications.  The general strategy is to attach a photosensitive reactive group … Continue reading

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Tetrahydrofuran Synthesis Using Fluorous Sulfonates.

Prof. Wei Zhang, currently located at UMass-Boston, has been using fluorous aryl sulfonates in library synthesis for some time now.  The fluorous aryl sulfonate can be used as a fluorous tag to facilitate purification of intermediates by fluorous solid phase … Continue reading

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Fluorous Surrogates for Methylated DNA

One of the most active areas of research in biology and chemical biology is in epigenetics which is the study of changes in gene expression through mechanisms other than a change in the gene sequence.  These can occur either through … Continue reading

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More Multi-Component Reaction Synthesis

Prof. Wei Zhang, formerly of FTI and now at UMass-Boston, has probably published more papers describing libraries made using fluorous methods than anyone else.  Many of these are multi-component reactions (MCRs) which usually combine 3 or more molecules to form … Continue reading

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Fluorous Diastereometric Mixture Synthesis (FDMS)

As part of FTI’s Pilot-Scale Libraries grant we synthesized a number of different libraries based on 3+2 cycloadditions.  During the preparation of one of these libraries we found that the synthetic pathway led to a number of different diastereomers being … Continue reading

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