Tag Archives: Total Synthesis

NMR Analysis of Natural Products with Multiple Stereocenters

Posted on November 9, 2011 by Marv

Over the last several years, Prof. Dennis Curran’s group has been synthesizing various natural products with multiple stereocenters using fluorous mixture synthesis (FMS).  Many of these natural products have been ones with stereocenters distal from each other.  What Prof. Curran … Continue reading →

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Efforts Toward the Synthesis of Ecteinascidin 597 by Pummerer Cyclization

Posted on August 25, 2011 by Marv

Prof. David Procter’s group at the University of Manchester have used fluorous thiols in the syntheses of a number of different molecular classes.  In each of these cases the goal of the research was to develop methods by which to … Continue reading →

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Fluorous Germyl-Stille Coupling

Posted on July 28, 2011 by Marv

Researchers at Imperial College led by Prof. Alan Spivey have over the last several years been developing methodology using fluorous tagged germanes in metal catalyzed coupling reactions.  They’ve found that these germanium compounds can be used in transformations analogous to … Continue reading →

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Fluorous Mixture Synthesis in Total Synthesis

Posted on April 7, 2010 by Marv

University of Pittsburgh professor and FTI founder, Dr. Dennis Curran, has extensively used fluorous mixture synthesis (FMS) in natural products chemistry.  In their quasiracemic approach, enantiomerically pure starting materials are labeled with a fluorous tag of specific length.  For example, … Continue reading →

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Fluorous Brassinosteroids

Posted on September 14, 2009 by Jeff

For a while now, medicinal chemists have incorporated fluorine into their molecules in order to impart desirable properties such as metabolic stability or increased lipophilicity.   More recently, the effects of longer fluorous chains have also been studied.  In a paper … Continue reading →

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