Tag Archives: Total Synthesis

NMR Analysis of Natural Products with Multiple Stereocenters

Over the last several years, Prof. Dennis Curran’s group has been synthesizing various natural products with multiple stereocenters using fluorous mixture synthesis (FMS).  Many of these natural products have been ones with stereocenters distal from each other.  What Prof. Curran … Continue reading

Posted in F HPLC, Mixture Synthesis, Small Molecule Synthesis | Tagged , , , | Comments Off

Efforts Toward the Synthesis of Ecteinascidin 597 by Pummerer Cyclization

Prof. David Procter’s group at the University of Manchester have used fluorous thiols in the syntheses of a number of different molecular classes.  In each of these cases the goal of the research was to develop methods by which to … Continue reading

Posted in Small Molecule Synthesis | Tagged , , , | Comments Off

Fluorous Germyl-Stille Coupling

Researchers at Imperial College led by Prof. Alan Spivey have over the last several years been developing methodology using fluorous tagged germanes in metal catalyzed coupling reactions.  They’ve found that these germanium compounds can be used in transformations analogous to … Continue reading

Posted in Assorted Fluorous Items, Small Molecule Synthesis | Tagged , , , , | Comments Off

Fluorous Mixture Synthesis in Total Synthesis

University of Pittsburgh professor and FTI founder, Dr. Dennis Curran, has extensively used fluorous mixture synthesis (FMS) in natural products chemistry.  In their quasiracemic approach, enantiomerically pure starting materials are labeled with a fluorous tag of specific length.  For example, … Continue reading

Posted in F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis | Tagged , , , , | Comments Off

Fluorous Brassinosteroids

For a while now, medicinal chemists have incorporated fluorine into their molecules in order to impart desirable properties such as metabolic stability or increased lipophilicity.   More recently, the effects of longer fluorous chains have also been studied.  In a paper … Continue reading

Posted in Small Molecule Synthesis | Tagged , | Comments Off