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Tag Archives: Thermomorphic
Thermomorphism in Therapeutics?
A just published ASAP paper in Inorganic Chemistry from the Dyson group describes their efforts in preparing potential anti-cancer agents which selectively target tumor cells. The selection criteria that they are attempting to exploit is temperature dependent solubility differences. Cancer … Continue reading
Fluorous molecules and carbon dioxide
A recent article in Journal of Supercritical Fluids from groups in Japan, China, and Taiwan describes the use of CO2 to tune fluorous Pd catalysts in Heck and Sonagashira reactions. The researchers conducted a simple Heck reaction (iodobenzene and methyl … Continue reading
Posted in Liquid-Liquid Extraction (LLE), Separation Techniques, Small Molecule Synthesis
Tagged biphasic catalysis, CO2, Heck reaction, Pd catalysis, Thermomorphic
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Thermomorphic perfluoroalkylated-pyridines catalyzing aldol condensation
Aldol condensation is one of the most fundamental and important carbon-carbon bond-forming reactions wherein an enolate ion reacts with a carbonyl compound to form a beta-hydroxyaldehyde or beta-hydroxyketone which upon dehydration results in a conjugated enone. The reactions are usually … Continue reading
Biphasic Catalysis Without Fluorous Solvents
In an recently online published article from Advanced Synthesis and Catalysis, Prof. John Gladysz and Florian Seidel describe their work using fluorous phosphines as catalysts in intramolecular cyclizations. The phosphine that they chose was one containing three fluorous chains as … Continue reading