Tag Archives: Thermomorphic

Fluorous Organocatalyzed Michael Addition

The number of fluorous organocatalysts and the number of reactions they catalyze is getting larger all the time.  The marriage of fluorous methods with organocatalysis is particularly attractive since organocatalysts can be costly and may require higher loading compared to … Continue reading

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Fluorous DABCO for the Morita-Bayliss-Hillman reaction

The Morita-Baylis-Hillman reaction is basically an aldol-type reaction which forms a carbon-carbon bond, generally between an aldehyde and an alpha, beta-unsaturated carbonyl.  The reaction is catalyzed by a nucleophile, usually an amine or phosphine, which adds reversibly to the beta … Continue reading

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Fluorous and Non-Fluorous Chemistry(continued)

The last couple of posts were about the use of hydrophobic surfaces produced by treating gold surfaces with alkanethiols.  One of the main themes in those posts was the nature and conformational structure of perfluoroalkyl domains vs. hydrocarbon chains.  Continuing … Continue reading

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Oxidation Using Fluorous IBX

Hypervalent iodine compounds are popular oxidizing agents for a number of good reasons.  They are generally very selective and mild which means that you can oxidize an alcohol for example in the presence of numerous other functional groups.  In addition … Continue reading

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Thermomorphic Metal Scavenging

Fluorous compounds generally have a steep temperature dependent solubility curve.  This has been exploited by several researchers in the design of catalysts and reagents which are in solution at higher reaction temperatures, but then precipitate out of solution upon cooling.  … Continue reading

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