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Tag Archives: Thermomorphic
Fluorous Organocatalyzed Michael Addition
The number of fluorous organocatalysts and the number of reactions they catalyze is getting larger all the time. The marriage of fluorous methods with organocatalysis is particularly attractive since organocatalysts can be costly and may require higher loading compared to … Continue reading
Posted in Small Molecule Synthesis
Tagged Michael addition, Miura, organocatalyst, Thermomorphic
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Fluorous DABCO for the Morita-Bayliss-Hillman reaction
The Morita-Baylis-Hillman reaction is basically an aldol-type reaction which forms a carbon-carbon bond, generally between an aldehyde and an alpha, beta-unsaturated carbonyl. The reaction is catalyzed by a nucleophile, usually an amine or phosphine, which adds reversibly to the beta … Continue reading
Posted in Assorted Fluorous Items, Small Molecule Synthesis
Tagged halogen bonding, Legros, Morita-baylis-Hillman, solvophobicity, Thermomorphic
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Fluorous and Non-Fluorous Chemistry(continued)
The last couple of posts were about the use of hydrophobic surfaces produced by treating gold surfaces with alkanethiols. One of the main themes in those posts was the nature and conformational structure of perfluoroalkyl domains vs. hydrocarbon chains. Continuing … Continue reading
Oxidation Using Fluorous IBX
Hypervalent iodine compounds are popular oxidizing agents for a number of good reasons. They are generally very selective and mild which means that you can oxidize an alcohol for example in the presence of numerous other functional groups. In addition … Continue reading
Posted in Scavengers and Reagents, Small Molecule Synthesis
Tagged IBX, Miura, oxidation, Thermomorphic
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