Tag Archives: photoaffinity

Isotope-coded Fluorous PALs

Prof. Qisheng Zhang at UNC-Chapel Hill has published several papers about the synthesis and use of fluorous tagged photoaffinity labels (PALs) and has just published another report in Chemical Communications.  The general strategy is to attach a photosensitive reactive group … Continue reading

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Fluorous PALs for Immobilization

Over the last couple of years there have been several reports by various research groups describing fluorous photoaffinity labeling agents (PALs).  These molecules have been aziridines with a fluorous tag attached such that upon exposure to UV light a carbene … Continue reading

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Fluorous Photoaffinity Labeling

Photoaffinity labeling reagents is a valuable way by which to study the interactions between two molecular entities.  Often times this is a ligand and it’s receptor.  The strategy is to attach the photolabel to a ligand, incubate with it’s binding … Continue reading

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Fluorous Photoaffinity Labeling

Late last year Prof. Qisheng Zhang at the University of North Carolina published a paper describing his group’s efforts at developing fluorous diazirines as photoaffinity labeling reagents.  For more details on Prof. Zhang’s work, you can view the presentation he … Continue reading

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Photoaffinity Labeling Reagents with Fluorous Tags

Photoaffinity labeling is a technique in proteomics by which to identify ligand binding sites in proteins or to study protein:protein interactions.  The label generally consists of three parts; a) a protein recognition or functional group reactive portion, b) a photoactive … Continue reading

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