Tag Archives: organocatalyst

Fluorous Organocatalyst for Aldol Reactions

Researchers at Gifu Pharmaceutical University led by Prof. Tsuyoshi Miura have been working on fluorous sulfonamide organocatalysts for some time now and have reported their results in various reactions.  These include asymmetric aldol reactions and Michael additions which we have … Continue reading

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September 2011 Technical Newsletter

The FTI Technical Newsletter and this blog are two of the primary methods by which we try to keep the fluorous research community aware of the latest scientific developments using fluorous methods.  F-Blog is primarily a “current events” format with … Continue reading

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Fluorous Organocatalyzed Michael Addition

The number of fluorous organocatalysts and the number of reactions they catalyze is getting larger all the time.  The marriage of fluorous methods with organocatalysis is particularly attractive since organocatalysts can be costly and may require higher loading compared to … Continue reading

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Fluorous Organocatalyzed Sulfide Oxidation

Organocatalysts have been an intense area of interest for organic chemists over the last 15 years or so.  As opposed to organometallic catalysts they exhibit lower toxicity and operational simplicity.  They do, however, have their drawbacks in comparison to metal … Continue reading

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Fluorous Solvents, Catalysts, and Green Chemistry

A new report in the journal Green Chemistry from Shibata and co-workers describes catalyst-free and catalytic Friedel-Crafts alkylation of indoles using a partially fluorous solvent, Solkane 365mfc, which is 1,1,1,3,3-pentafluorobutane.  The reaction depicted below between indole and trifluoropyruvate resulted in … Continue reading

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