Tag Archives: Oligonucleotides

Fluorous Surrogates for Methylated DNA

One of the most active areas of research in biology and chemical biology is in epigenetics which is the study of changes in gene expression through mechanisms other than a change in the gene sequence.  These can occur either through … Continue reading

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Synthetic Oligonucleotide Purification by Polymerization

An ASAP Organic Letters paper from Fang and Fueangfung at Michigan Technological University describes their work in using phase tags for the purification of synthetic oligonucleotides.  In this case the phase tag is a polymerizable tag attached to the terminal … Continue reading

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ISoFT ’09, Tuesday Report

Today was the big day for ISoFT’09 with lectures starting at 8 AM and lasting until 5 PM.  In total there was 18 talks with topics ranging from small molecule chemistry, materials, oligonucleotides, carbohydrates, sensors, and carbohydrates.  With that many … Continue reading

Posted in Biomolecule Synthesis, Carbohydrates, Life Science Applications, Oligonucleotides, Separation Techniques, Small Molecule Synthesis | Tagged , , , , , | 3 Comments

2009 Berry & Associates catalog

Fluorous techniques have been used by numerous research groups in the synthesis and purification of oligonucleotides with impressive results particularly with long oligos consisting of >50 nucleotides. FTI’s partner in oligonucleotide chemistry is Berry & Associates who have developed a … Continue reading

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ISoFT07 – Tuesday, July 31 report

The second full day of ISoFT07 was again a very intellectually stimulating day. The day started with two talks on fluorous carbohydrate synthesis, one delivered by Prof. Nicola Pohl of Iowa State University and the other by Prof. Mamuro Mizuno … Continue reading

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