Tag Archives: Nimzyme

Using Fluorous Tags to Mass Differentiate Stereospecific Reactions

Trent Northen and co-workers have been using fluorous immobilization in conjunction with nanostructure initiated mass spec (NIMS) in a number of different applications.  Dr. Northen was one of the inventors of NIMS while working in Gary Siuzdak’s labs at The … Continue reading

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NIMS and Nimzyme

In 2007, Prof. Gary Siuzdak and co-workers at The Scripps Research Institute introduced Nanostructure-Initiator mass spectrometry(NIMS) as a new surface-based mass analysis method. Just available online is a Analytical Chemistry “Feature” on NIMS describing its attributes, capabilities, and applications, primarily in … Continue reading

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Analysis of Biofluids by NIMS

Prof. Gary Siuzdak and co-workers at the Scripps Research Institute along with collaborators at Pfizer have just published a paper in Analytical Chemistry describing nanostructure initiated mass spectrometry (NIMS) in tissue and biofluid analysis.  They first reported the NIMS technique … Continue reading

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Fluorous Nanostructure-Initiator MS (NIMS)

Just published online is a very interesting PNAS paper from Profs. Chi-Huey Wong and Gary Siuzdak at Scripps describing their work in developing enzyme activity assays using MS detection. Specifically, they have extended the scope of the nanostructure-initiator MS (NIMS) … Continue reading

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