Tag Archives: natural products

Encode Information to your Molecules with Fluorous Tags

Fluorous tags, like the amine protecting group F17 Boc-ON, provide a lot of functions.  They can be attached and removed just like non-fluorous tags and similarly protect functional groups.  While attached to your molecule, the fluorous tag also allows for … Continue reading

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Fluorous Mixture Synthesis in Total Synthesis

University of Pittsburgh professor and FTI founder, Dr. Dennis Curran, has extensively used fluorous mixture synthesis (FMS) in natural products chemistry.  In their quasiracemic approach, enantiomerically pure starting materials are labeled with a fluorous tag of specific length.  For example, … Continue reading

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Natural Products-Like Library Review

As seen in the jasplakinolide post earlier this week, solid-supported natural product syntheses are often conducted with a goal of generating analogs as chemical probes and for SAR studies.  A review entitled “Advances in Solution and Solid-Phase Synthesis Toward the … Continue reading

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Maybe it is, maybe it isn’t?

Prof. Dennis Curran’s group at the University of Pittsburgh has recently reported their efforts in the synthesis and confirmation of stereostructure for (+)-cytostatin using fluorous mixture synthesis (Angew. Chem. 2008, 1130). (+)-Cytostatin is a selective inhibitor of protein phosphatase 2A … Continue reading

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Application of Fluorous Methodologies for the Purification of Natural Products

Here is an evidence of the utility of fluorous reagents to pharmacognosists and other chemists dealing with the natural products. In an upcoming article to be published in Tetrahedron Letters (doi:10.1016/j.tetlet.2007.06.077), for the first time, a fluorous tag – catch … Continue reading

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