Tag Archives: Multicomponent Reactions

More Multi-Component Reaction Synthesis

Prof. Wei Zhang, formerly of FTI and now at UMass-Boston, has probably published more papers describing libraries made using fluorous methods than anyone else.  Many of these are multi-component reactions (MCRs) which usually combine 3 or more molecules to form … Continue reading

Posted in Assorted Fluorous Items, FSPE, Separation Techniques, Small Molecule Synthesis | Tagged , , , | Comments Off

3-component Inverse Demand Diels-Alder

A recent paper from Liu and co-workers at the Shanghai Institute of Organic Chemistry describes a 3-component inverse demand aza Diels-Alder.  This communication caught our attention due to the use of perfluoroalkylsulfinamides.  The reaction as shown below results in a … Continue reading

Posted in Small Molecule Synthesis | Tagged , , , | Comments Off

Fluorous and Microwave

In Fluorous Technologies’ April Technical Newsletter we highlighted some recent examples from the literature demonstrating the use of fluorous methods in conjunction with other technologies.  One of the other technologies was microwave heating.  While we only showed one example in … Continue reading

Posted in FSPE, Separation Techniques, Small Molecule Synthesis | Tagged , , | Comments Off

Fluorous Isonitriles

A recent JOC article by Prof. Pirrung and coworkers describes synthesis and use of fluorous tagged isonitriles in multi-component reactions.  Previously, they reported synthesis of unsaturated isonitriles from oxazole and benzoxazole (J. Am. Chem. Soc. 2006, 128, 11772).  For example, … Continue reading

Posted in FSPE, Library Synthesis, Separation Techniques, Small Molecule Synthesis | Tagged , , , | 1 Comment

Fluorous Parallel Synthesis Successfully employed for Pilot Scale Library Grant

Last September, our grant proposal, “Diversity-Oriented Synthesis of Novel Heterocyclic and Natural Product-Like Libraries” was approved by the National Institutes of Health (NIH) as part of their Pilot Scale Libraries for High-Throughput Screening program. This program is part of the … Continue reading

Posted in Library Synthesis | Tagged | Comments Off