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Tag Archives: Multicomponent Reactions
Fluorous and Microwave
In Fluorous Technologies’ April Technical Newsletter we highlighted some recent examples from the literature demonstrating the use of fluorous methods in conjunction with other technologies. One of the other technologies was microwave heating. While we only showed one example in … Continue reading
Posted in FSPE, Separation Techniques, Small Molecule Synthesis
Tagged FSPE, Microwave, Multicomponent Reactions
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Fluorous Isonitriles
A recent JOC article by Prof. Pirrung and coworkers describes synthesis and use of fluorous tagged isonitriles in multi-component reactions. Previously, they reported synthesis of unsaturated isonitriles from oxazole and benzoxazole (J. Am. Chem. Soc. 2006, 128, 11772). For example, … Continue reading
Fluorous Parallel Synthesis Successfully employed for Pilot Scale Library Grant
Last September, our grant proposal, “Diversity-Oriented Synthesis of Novel Heterocyclic and Natural Product-Like Libraries” was approved by the National Institutes of Health (NIH) as part of their Pilot Scale Libraries for High-Throughput Screening program. This program is part of the … Continue reading
Library Synthesis using fluorous sulfonate tag
Recently, Bing Yan etc. published a paper (J. Comb. Chem. 2008, asap) on the synthesis of 2-aryl-substituted 4-thiazolidinone and 4-thiazinanone libraries as drug candidates. Fluorous sulfonate tag 3 was introduced and performed 2 functions during the syntheses: as a phase … Continue reading
J. Combinatorial Chemistry 2006 Review
The Journal of Combinatorial Chemistry every year publishes a survey of combinatorial techniques and libraries that were disclosed in the literature from the previous year. This year’s review covering 2006 is now available online. This is the 10th installment and … Continue reading
Posted in Library Synthesis, Mixture Synthesis
Tagged combinatorial chemistry, Microwave, Multicomponent Reactions
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