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Tag Archives: Multicomponent Reactions
More Multi-Component Reaction Synthesis
Prof. Wei Zhang, formerly of FTI and now at UMass-Boston, has probably published more papers describing libraries made using fluorous methods than anyone else. Many of these are multi-component reactions (MCRs) which usually combine 3 or more molecules to form … Continue reading
Posted in Assorted Fluorous Items, FSPE, Separation Techniques, Small Molecule Synthesis
Tagged FSPE, green chemistry, Multicomponent Reactions, Zhang
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3-component Inverse Demand Diels-Alder
A recent paper from Liu and co-workers at the Shanghai Institute of Organic Chemistry describes a 3-component inverse demand aza Diels-Alder. This communication caught our attention due to the use of perfluoroalkylsulfinamides. The reaction as shown below results in a … Continue reading
Posted in Small Molecule Synthesis
Tagged aza Diels-Alder, FSPE, Liu, Multicomponent Reactions
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Fluorous and Microwave
In Fluorous Technologies’ April Technical Newsletter we highlighted some recent examples from the literature demonstrating the use of fluorous methods in conjunction with other technologies. One of the other technologies was microwave heating. While we only showed one example in … Continue reading
Posted in FSPE, Separation Techniques, Small Molecule Synthesis
Tagged FSPE, Microwave, Multicomponent Reactions
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Fluorous Isonitriles
A recent JOC article by Prof. Pirrung and coworkers describes synthesis and use of fluorous tagged isonitriles in multi-component reactions. Previously, they reported synthesis of unsaturated isonitriles from oxazole and benzoxazole (J. Am. Chem. Soc. 2006, 128, 11772). For example, … Continue reading
Fluorous Parallel Synthesis Successfully employed for Pilot Scale Library Grant
Last September, our grant proposal, “Diversity-Oriented Synthesis of Novel Heterocyclic and Natural Product-Like Libraries” was approved by the National Institutes of Health (NIH) as part of their Pilot Scale Libraries for High-Throughput Screening program. This program is part of the … Continue reading