Tag Archives: Mitsunobu

Mitsunobu Reaction: Fluorous vs. MPEG

Posted on March 29, 2011 by Marv

Anyone which has conducted some organic synthesis has probably conducted Mitsunobu reactions for the formation of ethers, esters, or sulfonamides.  It’s really a great reaction which is conducted under mild conditions.  Usually the two substrates are an alcohol as the … Continue reading →

Posted in FSPE, Liquid-Liquid Extraction (LLE), Scavengers and Reagents, Separation Techniques, Small Molecule Synthesis | Tagged , , , , | 1 Comment

CO2 and Mitsunobu Conditions

Posted on March 4, 2010 by Marv

An Org. Letters ASAP paper from the Merck Research Labs in Boston reports the formation of ureas and carbamates using CO2.  The researchers reacted amines and anilines with CO2 catalyzed by DBU to form a carbamic acid intermediate.  This intermediate … Continue reading →

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Another Diazodicarboxylate for Mitsunobu Reactions

Posted on July 22, 2009 by Marv

The Mitsunobu reaction is one of the best methods for forming a heteroatom-carbon bond in a mild and selective fashion.  All you need is an acidic proton on the nucleophile functionality and an alcohol as the electrophilic precursor.  The reaction. … Continue reading →

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Mitsunobu reaction

Posted on April 23, 2009 by Marv

One of the most popular applications of fluorous chemistry has been in Mitsunobu reactions.  Almost everyone who has done some small molecule synthetic chemistry has conducted a Mitsunobu reaction at one time or another, since it’s a great reaction for … Continue reading →

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