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Tag Archives: Microarray
Fluorous PALs for Immobilization
Over the last couple of years there have been several reports by various research groups describing fluorous photoaffinity labeling agents (PALs). These molecules have been aziridines with a fluorous tag attached such that upon exposure to UV light a carbene … Continue reading
Posted in Assorted Fluorous Items, Life Science Applications, Microarray
Tagged Bradley, immobilization, Microarray, photoaffinity
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Upon Further Review
Over the past month or two several reviews have been published which mention or have fluorous sections within them. None of these reviews are dedicated to fluorous techniques, but rather to other topics where fluorous methods are just a part. … Continue reading
Posted in Assorted Fluorous Items, Biomolecule Synthesis, Life Science Applications, Microarray, Proteomics, Small Molecule Synthesis
Tagged immobilization, mass spec, Microarray, reviews, synthesis
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Glycan Arrays Using Hydrophobic Tags
One of the areas of research which we identified as growth areas for fluorous chemistry in 2011 was glycomics. Fluorous methods have already been shown to be highly useful in the synthesis, purification, and immobilization of carbohydrates. What remains then … Continue reading
Posted in Assorted Fluorous Items, Life Science Applications, Microarray
Tagged glycomics, Microarray, NIMS, Reichardt, Siuzdak, Wong
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Glycan Arrays with Direct MS Readout
Immobilization of fluorous tagged molecules onto a fluorous surface has been conducted by several groups for the formation of microarrays. Generally the surface has been a fluorous modified glass slide. Solutions containing the fluorous tagged probe are spotted on the … Continue reading
Posted in Life Science Applications, Microarray
Tagged cellulase, glycomics, immobilization, mass spec, Microarray, Wong
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Glycosphingolipid Analysis using Fluorous Tags
Glycosphingolipids (GSLs) are an important class of molecules which have been associated with several cellular functions including antigen activity, cell adhesion, and signal transduction. As the name suggests these molecules consist of a glycan portion and a lipid portion. Study … Continue reading
Posted in FSPE, Life Science Applications, Microarray, Proteomics
Tagged enrichment, glycomics, glycosphingolipids, mass spec, Microarray
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