Tag Archives: Microarray

Fluorous PALs for Immobilization

Over the last couple of years there have been several reports by various research groups describing fluorous photoaffinity labeling agents (PALs).  These molecules have been aziridines with a fluorous tag attached such that upon exposure to UV light a carbene … Continue reading

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Upon Further Review

Over the past month or two several reviews have been published which mention or have fluorous sections within them.  None of these reviews are dedicated to fluorous techniques, but rather to other topics where fluorous methods are just a part. … Continue reading

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Glycan Arrays Using Hydrophobic Tags

One of the areas of research which we identified as growth areas for fluorous chemistry in 2011 was glycomics.  Fluorous methods have already been shown to be highly useful in the synthesis, purification, and immobilization of carbohydrates.  What remains then … Continue reading

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Glycan Arrays with Direct MS Readout

Immobilization of fluorous tagged molecules onto a fluorous surface has been conducted by several groups for the formation of microarrays.  Generally the surface has been a fluorous modified glass slide.  Solutions containing the fluorous tagged probe are spotted on the … Continue reading

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Glycosphingolipid Analysis using Fluorous Tags

Glycosphingolipids (GSLs) are an important class of molecules which have been associated with several cellular functions including antigen activity, cell adhesion, and signal transduction.  As the name suggests these molecules consist of a glycan portion and a lipid portion.  Study … Continue reading

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