Topics
Keywords
ACS ACS meeting aldol asymmetric Biphasic biphasic catalysis carbohydrate Carbohydrates Catalysis combinatorial chemistry Diversity Oriented Synthesis enrichment Events FHPLC FLLE FMS FSPE glycomics green chemistry immobilization ISoFT '07 ISoFT'09 Isotope chemistry libraries Library Synthesis Materials Microarray microarray slides Microwave Multicomponent Reactions natural products newsletter NIMS olefin metathesis Oligonucleotides oligosaccharide organocatalyst Proteomics review samarium surfactant Thermomorphic Total Synthesis Triphasic Zhang
Tag Archives: Library Synthesis
Fluorous Diastereometric Mixture Synthesis (FDMS)
As part of FTI’s Pilot-Scale Libraries grant we synthesized a number of different libraries based on 3+2 cycloadditions. During the preparation of one of these libraries we found that the synthetic pathway led to a number of different diastereomers being … Continue reading
Posted in FSPE, Library Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged FDMS, FMS, Library Synthesis, Zhang
Comments Off
Small Molecule Library Synthesis
Our latest Technical Newsletter was focused on small molecule synthesis and the advantages of using fluorous methods in the preparation of libraries of interesting chemical motifs. Coincidentally, a just available J. Org. Chem paper from Profs. Sanz-Cervera and Fustero describe … Continue reading
Posted in FSPE, Library Synthesis, Small Molecule Synthesis
Tagged FSPE, Library Synthesis, oxazole, thiazole
Comments Off
Parallel Benzodiazpinedione Synthesis
A group of researchers led by Prof. Bing Yan have just published their use of fluorous tags in benzodiazopinedione synthesis in J. Comb. Chem. The general reaction scheme is shown below. The researchers chose to use a fluorous sulfonyl tag … Continue reading
Posted in FSPE, Library Synthesis, Small Molecule Synthesis
Tagged benzodiazopine, FSPE, Library Synthesis, Microwave, Suzuki, Ugi
Comments Off
Fluorous Isonitriles
A recent JOC article by Prof. Pirrung and coworkers describes synthesis and use of fluorous tagged isonitriles in multi-component reactions. Previously, they reported synthesis of unsaturated isonitriles from oxazole and benzoxazole (J. Am. Chem. Soc. 2006, 128, 11772). For example, … Continue reading
Multi-Component Reactions Using Fluorous tags
An J. Combi. Chem. ASAP paper from the Center for Chemical Methodologies and Library Design at the University of Pittsburgh describes the synthesis of a 90-member fused piperazinedione library. The key first step in the synthesis is a multi-component reaction … Continue reading
Posted in FSPE, Library Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged CMLD, combinatorial chemistry, FSPE, libraries, Library Synthesis, Microwave, University of Pittsburgh
Comments Off