Tag Archives: Library Synthesis

Fluorous Diastereometric Mixture Synthesis (FDMS)

As part of FTI’s Pilot-Scale Libraries grant we synthesized a number of different libraries based on 3+2 cycloadditions.  During the preparation of one of these libraries we found that the synthetic pathway led to a number of different diastereomers being … Continue reading

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Small Molecule Library Synthesis

Our latest Technical Newsletter was focused on small molecule synthesis and the advantages of using fluorous methods in the preparation of libraries of interesting chemical motifs.  Coincidentally, a just available J. Org. Chem paper from Profs. Sanz-Cervera and Fustero describe … Continue reading

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Parallel Benzodiazpinedione Synthesis

A group of researchers led by Prof. Bing Yan have just published their use of fluorous tags in benzodiazopinedione synthesis in J. Comb. Chem. The general reaction scheme is shown below.   The researchers chose to use a fluorous sulfonyl tag … Continue reading

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Fluorous Isonitriles

A recent JOC article by Prof. Pirrung and coworkers describes synthesis and use of fluorous tagged isonitriles in multi-component reactions.  Previously, they reported synthesis of unsaturated isonitriles from oxazole and benzoxazole (J. Am. Chem. Soc. 2006, 128, 11772).  For example, … Continue reading

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Multi-Component Reactions Using Fluorous tags

An J. Combi. Chem. ASAP paper from the Center for Chemical Methodologies and Library Design at the University of Pittsburgh describes the synthesis of a 90-member fused piperazinedione library.  The key first step in the synthesis is a multi-component reaction … Continue reading

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