Tag Archives: libraries

Evaluating FTI Chemical Libraries

To date fluorous methods have been used for small molecule synthesis more than any other application.  The value of using fluorous techniques is that it provides a versatile, easy, and reliable and method for the purification of synthetic intermediates and … Continue reading

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Look closely

Right on the heels of their publication of two months ago, Profs. Yan and Zhang have published a new paper on the synthesis of benzodiazepinedione libraries using fluorous techniques.  F-Blog highlighted the first paper and this one looks very similar.  … Continue reading

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Multi-Component Reactions Using Fluorous tags

An J. Combi. Chem. ASAP paper from the Center for Chemical Methodologies and Library Design at the University of Pittsburgh describes the synthesis of a 90-member fused piperazinedione library.  The key first step in the synthesis is a multi-component reaction … Continue reading

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Natural Products-Like Library Review

As seen in the jasplakinolide post earlier this week, solid-supported natural product syntheses are often conducted with a goal of generating analogs as chemical probes and for SAR studies.  A review entitled “Advances in Solution and Solid-Phase Synthesis Toward the … Continue reading

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Saved by F-Boc

Some reactions are hard to reach to a high conversion, and require a large excess of reagents under harsher conditions.  That may lead to a painful workup and purification to isolate the desired products from the messy mixture of the … Continue reading

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