Tag Archives: green chemistry

More Fun with Fluorous Solvents

Shibata and co-workers at Nagoya Institute of Technology have already published several papers running reactions in hydrofluorocarbon solvents.  Their solvent of choice has been Solkane 365 mfc which is 1,1,1,3,3-pentafluorobutane, CH3-CF2-CH2-CF3.  Solkane 365 mfc is produced by Solvay Fluor GmbH … Continue reading

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More Multi-Component Reaction Synthesis

Prof. Wei Zhang, formerly of FTI and now at UMass-Boston, has probably published more papers describing libraries made using fluorous methods than anyone else.  Many of these are multi-component reactions (MCRs) which usually combine 3 or more molecules to form … Continue reading

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Fluorous Solvents, Catalysts, and Green Chemistry

A new report in the journal Green Chemistry from Shibata and co-workers describes catalyst-free and catalytic Friedel-Crafts alkylation of indoles using a partially fluorous solvent, Solkane 365mfc, which is 1,1,1,3,3-pentafluorobutane.  The reaction depicted below between indole and trifluoropyruvate resulted in … Continue reading

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Alternative Fluorous Tags for Greener Chemistry

As readers of this blog are aware, most fluorous tags are straight-chain perfluoroalkyl groups, such as C4F9, C6F13, or C8F17.  Fluorous chemistry at the outset was viewed as green chemistry since one could easily recover and recycle the fluorous tagged … Continue reading

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Is Fluorous Chemistry Green?

On the heels of a review about sustainable chemistry for heterocycle synthesis is a “critical review” in the journal Green Chemistry from Prof. Wei Zhang at UMass-Boston.  The review is entitled, ” Green chemistry aspects of fluorous techniques – opportunities … Continue reading

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