Tag Archives: FSPE

Visual Monitoring of Fluorous Solid Phase Extraction (FSPE)

The fluorous solid-phase extraction (FSPE) process is a very robust and  general process.  It’s utility and applicability have been demonstrated over a range of substrates and molecular classes.  One of the great things is the ease of operation.  One wash … Continue reading

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Isotope-coded Fluorous PALs

Prof. Qisheng Zhang at UNC-Chapel Hill has published several papers about the synthesis and use of fluorous tagged photoaffinity labels (PALs) and has just published another report in Chemical Communications.  The general strategy is to attach a photosensitive reactive group … Continue reading

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Fluorous Supported Synthesis of Teichoic Acid Fragments

Oligonucleotides, proteins, peptides, and carbohydrates are the best known biopolymers and one doesn’t have to explain how important each is to a number of biological functions.  The synthesis of these materials, or segments of them, are important in order to … Continue reading

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Fluorous Organocatalyst for Aldol Reactions

Researchers at Gifu Pharmaceutical University led by Prof. Tsuyoshi Miura have been working on fluorous sulfonamide organocatalysts for some time now and have reported their results in various reactions.  These include asymmetric aldol reactions and Michael additions which we have … Continue reading

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Diversity Oriented Synthesis Using Fluorous Tags

Diversity-oriented synthesis (DOS) has been discussed here often and the benefits of employing fluorous tags and purification methods to the construction of such libraries has been effectively established.  Among these are the solution phase nature of the chemistry, the general … Continue reading

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