Topics
Keywords
ACS ACS meeting asymmetric Biphasic biphasic catalysis carbohydrate Carbohydrates Catalysis combinatorial chemistry Diversity Oriented Synthesis DOS enrichment Events F-Blog FLLE FMS FSPE ISoFT '07 ISoFT'09 Isotope chemistry libraries Library Synthesis Materials Microarray microarray slides Microwave Multicomponent Reactions natural products newsletter NIMS olefin metathesis Oligonucleotides oligosaccharide organocatalyst phase vanishing Proteomics Quality Control review samarium Sigma Aldrich surfactant Thermomorphic Total Synthesis Triphasic User Interview
Tag Archives: FMS
In vivo fluorous mixture synthesis
The Hatanaka group has been studying the in vivo glycosylation of fluorous tagged carbohydrates for several years. They have found that various fluorous tagged sugar primers introduced to a culture medium can cross cell membranes, be enzymatically glycosylated, then exit … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Mixture Synthesis
Tagged FMS, FSPE, FTLC, in vivo glycosylation, oligosaccharide
Comments Off
Fluorous Mixture Sunthesis in Total Synthesis
University of Pittsburgh professor and FTI founder, Dr. Dennis Curran, has extensively used fluorous mixture synthesis (FMS) in natural products chemistry. In their quasiracemic approach, enantiomerically pure starting materials are labeled with a fluorous tag of specific length. For example, … Continue reading
Posted in F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged FMS, natural products, quasiracemic synthesis, tetrafibricin, Total Synthesis
Comments Off
Fluorous Mixture Synthesis of Dendrimers
In June of last year, the Yu group from the University of Maryland published a report in Angewandte Chemie describing the synthesis of a fluorous dendrimer as a 19F MRI imaging agent. The molecule, dubbed FIT, is pictured below and … Continue reading
Posted in F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged 19F MRI, dendrimers, FIT, FMS
Comments Off
Total synthesis of macrocyclic glycosides
Prof. Seiji Takeuchi at Niigata University has recently published a paper describing his group’s efforts at the total synthesis of three closely related macrocyclic glycosides. These three are clemochinenoside A, clemochinenoside B, and berchemolide. As seen in the figure below, … Continue reading
Posted in Carbohydrates, FSPE, Mixture Synthesis, Separation Techniques
Tagged Carbohydrates, F HPLC, FMS, FSPE
Comments Off
Assigning absolute stereochemistry
Anyone who has done a total synthesis of a chiral molecule or worked on chiral methodology is probably quite familiar with Mosher esters. A chiral alcohol can be derivitized with both (R) and (S)- 2-methoxy-2-trifluoromethyl-2-phenyl acetic acid (MTPA) to form … Continue reading
Posted in Mixture Synthesis, Small Molecule Synthesis
Tagged FMS, Mosher ester, petrocortyne, Total Synthesis
Comments Off