Tag Archives: fluorophilicity

Perfluoropolyethers as Fluorous Tags

For the most part fluorous domains used in fluorous biphasic systems have been linear perfluoroalkyls, such as perfluorooctyl moieties.  Branched perfluoralkyls such as perfluorinated t-butyl groups have also been used as tags to facilitate fluorous based separations.  In the 2004 … Continue reading

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Predicting Fluorophilicity, Part II

Late in 2009, a group led by Prof. Hu at Zhejiang University published a paper where they predicted fluorous partition coefficients using computational methods.  We wrote about that work in F-blog at the time here.  The paper reports that they … Continue reading

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Predicting Fluorophilicity

One of the most important components in fluorous chemistry is fluorophilicity.  This is generally experimentally measured and expressed in terms of a partition coefficient (ln P) of a molecule between equal volumes of perfluoromethylcyclohexane (CF3C6F11) and toluene.  The actual equation … Continue reading

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