Tag Archives: FLLE

Fluorous Solvents for Liquid-Liquid Extraction

As the regular reader of F-Blog knows, fluorous liquid-liquid extraction (FLLE) is, along with fluorous solid phase extraction (FSPE) one of the primary methods to conduct fluorous separations.  In fact,  FLLE was the original fluorous separation method as applied to … Continue reading

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Fluorous Swern Reaction

The Swern reaction is a very mild and selective method for the oxidation of alcohols to aldehydes and ketones, but suffers from the formation of volatile malodorous dimethyl sulfide.  Just about anyone who has spent time in a synthetic chemistry … Continue reading

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Increasing Fluorophilicity by Hydrogen Bonding

As most readers of F-Blog will know, the original embodiment of fluorous chemistry was in biphasic catalysis where a fluorous modified catalyst was essentially immobilized in a fluorous liquid phase, most commonly a perfluorocarbon solvent.  These solvents are highly non-polarizable … Continue reading

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Removal of Metals by Fluorous Extraction

Prof. Robert Baker and co-workers have been working on methods for the removal of low levels of metals and radionuclides for wastewater samples through fluorous methods for some time.  We reported on one of those methods which was a fluorous … Continue reading

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Mitsunobu Reaction: Fluorous vs. MPEG

Anyone which has conducted some organic synthesis has probably conducted Mitsunobu reactions for the formation of ethers, esters, or sulfonamides.  It’s really a great reaction which is conducted under mild conditions.  Usually the two substrates are an alcohol as the … Continue reading

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