Tag Archives: FHPLC

Orthogonal Fluorous Mixture Synthesis (FMS)

University of Pittsburgh Professor and Fluorous Technologies, Inc. founder, Dennis Curran, has over the last several years dedicated a good portion of his research to fluorous mixture synthesis (FMS).  In FMS, libraries or isomers of compounds can be made in … Continue reading

Posted in Assorted Fluorous Items, F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis | Tagged , , , | Comments Off

NMR Analysis of Natural Products with Multiple Stereocenters

Over the last several years, Prof. Dennis Curran’s group has been synthesizing various natural products with multiple stereocenters using fluorous mixture synthesis (FMS).  Many of these natural products have been ones with stereocenters distal from each other.  What Prof. Curran … Continue reading

Posted in F HPLC, Mixture Synthesis, Small Molecule Synthesis | Tagged , , , | Comments Off

Fluorous Mixture Synthesis of Cucurbitosides

In 2008 the Takeuchi group at Niigata University reported the total synthesis of cucurbitoside A, one of a series partially acylated phenolic glycosides.  The cucurbitosides are found in the seeds of squashes and pumpkins of the genus Cucurbita.  Water extracts … Continue reading

Posted in Assorted Fluorous Items, Carbohydrates, F HPLC, Separation Techniques | Tagged , , , , | Comments Off

Macrocycle Formation using Fluorous Methods

Macrocyclic compounds are some of the most interesting compounds known, both in terms of biological function and synthetic challenge.  The best known macrocyclic compounds are probably the macrocyclic antibiotics like erythromycin and vancomycin, but other molecules such as the taxenes … Continue reading

Posted in Assorted Fluorous Items | Tagged , , , , , , | Comments Off

Fluorous Separations using Microstructured Fibers

Last week we published a post describing Prof. Richard Oleschuk’s work using fluorous polymer monoliths as a fluorous separation media.  As noted within that post, despite the demonstrated utility of fluorous based separations nearly all of the fluorous solid phase … Continue reading

Posted in F HPLC, Separation Techniques | Tagged , , | Comments Off