Tag Archives: Diversity Oriented Synthesis

Diversity Oriented Synthesis Using Fluorous Tags

Posted on January 3, 2012 by Marv

Diversity-oriented synthesis (DOS) has been discussed here often and the benefits of employing fluorous tags and purification methods to the construction of such libraries has been effectively established.  Among these are the solution phase nature of the chemistry, the general … Continue reading →

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More Diversity-Oriented Synthesis

Posted on October 13, 2011 by Marv

One of the more contentious topics amongst organic chemists is diversity-oriented synthesis (DOS), the preparation of libraries of chemically diverse molecular scaffolds or ring systems.  Some view it as a critical challenge for chemists and particularly for the pharmaceutical industry … Continue reading →

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Combinatorial Libraries: Where to?

Posted on June 28, 2011 by Marv

The earliest envisioned applications of any technology are not always the ones that end up being the most powerful or popular application.  A good example would be RFID tags, the predecessor of which developed in 1945 in the USSR as … Continue reading →

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Natural Products or Diversity-Oriented Synthesis

Posted on July 13, 2010 by Marv

Given the current state of the pharmaceutical industry and their ever dropping research productivity as measured by new drugs on the market, there is considerable debate regarding the best strategies to find new targets, leads, and ultimately, drugs.  One thing … Continue reading →

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Diversity Oriented Synthesis Update

Posted on January 13, 2009 by Marv

Back in November, we published a F-Blog post which highlighted the work of Prof. Adam Nelson which described his use of a fluorous linker and olefin metathesis chemistry in diversity-oriented synthesis (DOS).  The library produced had an unprecedented level of … Continue reading →

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