Topics
Keywords
ACS ACS meeting aldol asymmetric Biphasic biphasic catalysis carbohydrate Carbohydrates Catalysis combinatorial chemistry Diversity Oriented Synthesis enrichment Events FHPLC FLLE FMS FSPE glycomics green chemistry immobilization ISoFT '07 ISoFT'09 Isotope chemistry libraries Library Synthesis Materials Microarray microarray slides Microwave Multicomponent Reactions natural products newsletter NIMS olefin metathesis Oligonucleotides oligosaccharide organocatalyst Proteomics review samarium surfactant Thermomorphic Total Synthesis Triphasic Zhang
Search Results for: photoaffinity
Isotope-coded Fluorous PALs
Prof. Qisheng Zhang at UNC-Chapel Hill has published several papers about the synthesis and use of fluorous tagged photoaffinity labels (PALs) and has just published another report in Chemical Communications. The general strategy is to attach a photosensitive reactive group … Continue reading
Posted in Life Science Applications, Proteomics
Tagged FSPE, photoaffinity, Proteomics, Zhang
Comments Off
Fluorous Surrogates for Methylated DNA
One of the most active areas of research in biology and chemical biology is in epigenetics which is the study of changes in gene expression through mechanisms other than a change in the gene sequence. These can occur either through … Continue reading
Posted in Assorted Fluorous Items, Biomolecule Synthesis, Life Science Applications, Oligonucleotides
Tagged epigenetics, FSPE, Oligonucleotides, Zhang
Comments Off
Fluorous PALs for Immobilization
Over the last couple of years there have been several reports by various research groups describing fluorous photoaffinity labeling agents (PALs). These molecules have been aziridines with a fluorous tag attached such that upon exposure to UV light a carbene … Continue reading
Posted in Assorted Fluorous Items, Life Science Applications, Microarray
Tagged Bradley, immobilization, Microarray, photoaffinity
Comments Off
Biomolecule Labeling: Fluorous Luminescence
The labeling of biomolecules with exogenous reagents is generally done for one of two purposes either enrichment or detection. Enrichment labeling is generally in the form of some sort of affinity tag such as biotin, a His tag, and yes, … Continue reading
Posted in Life Science Applications, Proteomics
Tagged FSPE, Lo, Proteomics, trifunctional tag
Comments Off
More Photoaffinity Labeling
A couple of weeks ago, we published a post describing the work of Manetsch et al in the development of fluorous photoaffinity labels. The researchers from the University of South Florida were working on preparing fluorous tagged diazirines and found … Continue reading
Posted in Assorted Fluorous Items
Comments Off