Search Results for: photoaffinity

Isotope-coded Fluorous PALs

Prof. Qisheng Zhang at UNC-Chapel Hill has published several papers about the synthesis and use of fluorous tagged photoaffinity labels (PALs) and has just published another report in Chemical Communications.  The general strategy is to attach a photosensitive reactive group … Continue reading

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Fluorous Surrogates for Methylated DNA

One of the most active areas of research in biology and chemical biology is in epigenetics which is the study of changes in gene expression through mechanisms other than a change in the gene sequence.  These can occur either through … Continue reading

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Fluorous PALs for Immobilization

Over the last couple of years there have been several reports by various research groups describing fluorous photoaffinity labeling agents (PALs).  These molecules have been aziridines with a fluorous tag attached such that upon exposure to UV light a carbene … Continue reading

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Biomolecule Labeling: Fluorous Luminescence

The labeling of biomolecules with exogenous reagents is generally done for one of two purposes either enrichment or detection.  Enrichment labeling is generally in the form of some sort of affinity tag such as biotin, a His tag, and yes, … Continue reading

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More Photoaffinity Labeling

A couple of weeks ago, we published a post describing the work of Manetsch et al in the development of fluorous photoaffinity labels.  The researchers from the University of South Florida were working on preparing fluorous tagged diazirines and found … Continue reading

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