Comments for F-Blog http://www.fluorous.com/journal All things Fluorous Thu, 02 Jun 2011 13:08:51 +0000 hourly 1 http://wordpress.org/?v=3.3.1 Comment on Fluorous Scavenging for Radioimaging Agent Production by Marv http://www.fluorous.com/journal/?p=2371&cpage=1#comment-3344 Marv Thu, 02 Jun 2011 13:08:51 +0000 http://www.fluorous.com/journal/?p=2371#comment-3344 Milkshake, Isotope chemistry is definitely one area which we believe fluorous can shine. Anytime you have a high-value substance that needs to be purified it certainly makes the case for fluorous methods easier to see. Thanks for commenting. Milkshake,

Isotope chemistry is definitely one area which we believe fluorous can shine. Anytime you have a high-value substance that needs to be purified it certainly makes the case for fluorous methods easier to see.

Thanks for commenting.

]]> Comment on Fluorous Scavenging for Radioimaging Agent Production by milkshake http://www.fluorous.com/journal/?p=2371&cpage=1#comment-3343 milkshake Wed, 01 Jun 2011 02:15:24 +0000 http://www.fluorous.com/journal/?p=2371#comment-3343 I was always troubled by the fairly high cost and high-molecular-weight modifications inherent in FLC - when i considered using it for traditional medicinal chemistry. It seemed to me that fluorous chemistry was more likely to be attractive in a niche application, much like solid phase-supported chemistry found common use in the synthesis of peptides and oligonucleotides. I think radiolabeling with short-lived radionuclides for diagnostics could be the perfect niche for FLC. I was always troubled by the fairly high cost and high-molecular-weight modifications inherent in FLC – when i considered using it for traditional medicinal chemistry. It seemed to me that fluorous chemistry was more likely to be attractive in a niche application, much like solid phase-supported chemistry found common use in the synthesis of peptides and oligonucleotides. I think radiolabeling with short-lived radionuclides for diagnostics could be the perfect niche for FLC.

]]> Comment on Perfluoroalkyl sulfinamides as chiral auxillaries by Marv http://www.fluorous.com/journal/?p=2331&cpage=1#comment-3311 Marv Tue, 03 May 2011 13:13:15 +0000 http://www.fluorous.com/journal/?p=2331#comment-3311 My bad. Corrected, milkshake. Thanks for the correction. My bad. Corrected, milkshake. Thanks for the correction.

]]> Comment on Perfluoroalkyl sulfinamides as chiral auxillaries by milkshake http://www.fluorous.com/journal/?p=2331&cpage=1#comment-3310 milkshake Tue, 03 May 2011 04:24:10 +0000 http://www.fluorous.com/journal/?p=2331#comment-3310 sorry for being a terminology Nazi but it is sulfinimides and sulfinimines because it has a sulfinyl group (RSO-) - not sulfonyl (RSO2). It would not be chiral with a sulfonyl group. sorry for being a terminology Nazi but it is sulfinimides and sulfinimines because it has a sulfinyl group (RSO-) – not sulfonyl (RSO2). It would not be chiral with a sulfonyl group.

]]> Comment on More Fun with Fluorous Solvents by Marv http://www.fluorous.com/journal/?p=2284&cpage=1#comment-3264 Marv Mon, 11 Apr 2011 14:21:32 +0000 http://www.fluorous.com/journal/?p=2284#comment-3264 I actually did not know that about partially fluorinated solvents increased gas solubility, milkshake. Your comment about the flammability of organic solvents in O2 rich environments is well worth noting. Thanks for the input. I actually did not know that about partially fluorinated solvents increased gas solubility, milkshake. Your comment about the flammability of organic solvents in O2 rich environments is well worth noting.

Thanks for the input.

]]> Comment on More Fun with Fluorous Solvents by milkshake http://www.fluorous.com/journal/?p=2284&cpage=1#comment-3262 milkshake Mon, 11 Apr 2011 13:20:45 +0000 http://www.fluorous.com/journal/?p=2284#comment-3262 Even partially fluorinated hydrocarbons have increased oxygen solubility - I was looking at 1,3-bis-trifluoromethylbenzene few years back and I remember it was at least twice the oxygen solubility in plain xylene. Another problem is flammability/explosivity of common organic solvents with pure oxygen, which makes oxidations using pure O2 very unpopular in the industry. So if this perfluoro solvent is cheap enough and recyclable, it could be worth trying in such a process. Even partially fluorinated hydrocarbons have increased oxygen solubility – I was looking at 1,3-bis-trifluoromethylbenzene few years back and I remember it was at least twice the oxygen solubility in plain xylene.

Another problem is flammability/explosivity of common organic solvents with pure oxygen, which makes oxidations using pure O2 very unpopular in the industry. So if this perfluoro solvent is cheap enough and recyclable, it could be worth trying in such a process.

]]> Comment on Mitsunobu Reaction: Fluorous vs. MPEG by milkshake http://www.fluorous.com/journal/?p=2276&cpage=1#comment-3212 milkshake Wed, 30 Mar 2011 21:02:33 +0000 http://www.fluorous.com/journal/?p=2276#comment-3212 Another problem with PEG- modified reagents is with their hygroscopicity and poor crystallinity. (No need for extra water in your Mitsunobu). Silica column will bind strongly all basic and highly polar products so this limits the scope of useful substrates (for example you cannot use aminoalcohols as Mitsunobu partners in this case). Also, any cost comparison between a commercial and non-commercial alternative is problematic, to make a good argument they would need to reproduce the synthesis of the commercial fluorous reagents in their lab to see if they could make it significantly cheaper Another problem with PEG- modified reagents is with their hygroscopicity and poor crystallinity. (No need for extra water in your Mitsunobu). Silica column will bind strongly all basic and highly polar products so this limits the scope of useful substrates (for example you cannot use aminoalcohols as Mitsunobu partners in this case). Also, any cost comparison between a commercial and non-commercial alternative is problematic, to make a good argument they would need to reproduce the synthesis of the commercial fluorous reagents in their lab to see if they could make it significantly cheaper

]]> Comment on EndNotes Databases of Fluorous References Updated by Marv http://www.fluorous.com/journal/?p=2179&cpage=1#comment-2999 Marv Tue, 15 Feb 2011 14:03:26 +0000 http://www.fluorous.com/journal/?p=2179#comment-2999 Lawrence, We are having some issues with the complete reference database for some reason. Send us your email address through contact-fti@fluorous.com and we'll send it directly to you. Lawrence,

We are having some issues with the complete reference database for some reason.

Send us your email address through contact-fti@fluorous.com and we’ll send it directly to you.

]]> Comment on EndNotes Databases of Fluorous References Updated by Lawrence Morgan http://www.fluorous.com/journal/?p=2179&cpage=1#comment-2992 Lawrence Morgan Tue, 15 Feb 2011 01:24:16 +0000 http://www.fluorous.com/journal/?p=2179#comment-2992 Fluorous_references.enl, 4.2MB, (your file?) at http://www.sigmaaldrich.com/chemistry/chemical-synthesis/flourous/learning-center/fluorus-application.html opens without a problem. Fluorous_references.enl, 4.2MB, (your file?) at http://www.sigmaaldrich.com/chemistry/chemical-synthesis/flourous/learning-center/fluorus-application.html opens without a problem.

]]> Comment on EndNotes Databases of Fluorous References Updated by Lawrence Morgan http://www.fluorous.com/journal/?p=2179&cpage=1#comment-2991 Lawrence Morgan Mon, 14 Feb 2011 19:56:33 +0000 http://www.fluorous.com/journal/?p=2179#comment-2991 Fluorous_references.enl can't be opened or recovered from either version. Fluorous_references.enl can’t be opened or recovered from either version.

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