Category Archives: Separation Techniques

Orthogonal Fluorous Mixture Synthesis (FMS)

University of Pittsburgh Professor and Fluorous Technologies, Inc. founder, Dennis Curran, has over the last several years dedicated a good portion of his research to fluorous mixture synthesis (FMS).  In FMS, libraries or isomers of compounds can be made in … Continue reading

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Diversity Oriented Synthesis Using Fluorous Tags

Diversity-oriented synthesis (DOS) has been discussed here often and the benefits of employing fluorous tags and purification methods to the construction of such libraries has been effectively established.  Among these are the solution phase nature of the chemistry, the general … Continue reading

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Tetrahydrofuran Synthesis Using Fluorous Sulfonates.

Prof. Wei Zhang, currently located at UMass-Boston, has been using fluorous aryl sulfonates in library synthesis for some time now.  The fluorous aryl sulfonate can be used as a fluorous tag to facilitate purification of intermediates by fluorous solid phase … Continue reading

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18F Radiolabeled Compounds Using Fluorous and Click Chemistry

About one year ago Prof. Veronique Gouverneur described the synthesis of a 18F substituted azide which they used in Staudinger ligations to form 18F containing amides which could be used in PET imaging.  Prior to that they have used the … Continue reading

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NMR Analysis of Natural Products with Multiple Stereocenters

Over the last several years, Prof. Dennis Curran’s group has been synthesizing various natural products with multiple stereocenters using fluorous mixture synthesis (FMS).  Many of these natural products have been ones with stereocenters distal from each other.  What Prof. Curran … Continue reading

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