Category Archives: Scavengers and Reagents

More Fluorous Organocatalysts

Posted on April 1, 2010 by Marv

Two weeks ago we described work by the Miura group at Gifu University using a fluorous tagged organocatalyst in asymmetric aldol reactions.  These reactions were run in brine, the reaction mixtures directly applied to a FSPE cartridge, and the fluorous … Continue reading →

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F-NH3

Posted on March 26, 2010 by Marv

The formation and preparation of nitrogen containing molecules is one of obvious importance in organic chemistry and particularly in medicinal chemistry.  There’s not many classes of drugs that don’t contain a nitrogen or two (steroids and prostaglandins come to mind) … Continue reading →

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CO2 and Mitsunobu Conditions

Posted on March 4, 2010 by Marv

An Org. Letters ASAP paper from the Merck Research Labs in Boston reports the formation of ureas and carbamates using CO2.  The researchers reacted amines and anilines with CO2 catalyzed by DBU to form a carbamic acid intermediate.  This intermediate … Continue reading →

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Thermomorphic Metal Scavenging

Posted on February 19, 2010 by Marv

Fluorous compounds generally have a steep temperature dependent solubility curve.  This has been exploited by several researchers in the design of catalysts and reagents which are in solution at higher reaction temperatures, but then precipitate out of solution upon cooling.  … Continue reading →

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Tagging vs. Scavenging vs. Nothing

Posted on January 8, 2010 by Marv

One of the grants from NIH that we have secured at FTI is a Pilot-Scale Libraries grant for the production and depositing of compounds into NIH’s screening collection, the Molecular Libraries Small Molecules Repository (MLSMR).  The MLSMR is part of … Continue reading →

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