Category Archives: Mixture Synthesis

In vivo fluorous mixture synthesis

The Hatanaka group has been studying the in vivo glycosylation of fluorous tagged carbohydrates for several years.  They have found that various fluorous tagged sugar primers introduced to a culture medium can cross cell membranes, be enzymatically glycosylated, then exit … Continue reading

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Fluorous Mixture Synthesis in Total Synthesis

University of Pittsburgh professor and FTI founder, Dr. Dennis Curran, has extensively used fluorous mixture synthesis (FMS) in natural products chemistry.  In their quasiracemic approach, enantiomerically pure starting materials are labeled with a fluorous tag of specific length.  For example, … Continue reading

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Fluorous Mixture Synthesis of Dendrimers

In June of last year, the Yu group from the University of Maryland published a report in Angewandte Chemie describing the synthesis of a fluorous dendrimer as a 19F MRI imaging agent.  The molecule, dubbed FIT, is pictured below and … Continue reading

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Synthesis of Resorcylic Acid Lactones

Two interesting Early View papers from Chemistry-A European Journal from Prof. Nicolas Winssinger’s group have recently been published online.  Both papers are centered on the synthesis of resorcylic acid lactones.  These benzannulated macrolactones have garnered interest due to their inhibitory … Continue reading

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Total synthesis of macrocyclic glycosides

Prof. Seiji Takeuchi at Niigata University has recently published a paper describing his group’s efforts at the total synthesis of three closely related macrocyclic glycosides. These three are clemochinenoside A, clemochinenoside B, and berchemolide.  As seen in the figure below, … Continue reading

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