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Category Archives: Mixture Synthesis
Encode Information to your Molecules with Fluorous Tags
Fluorous tags, like the amine protecting group F17 Boc-ON, provide a lot of functions. They can be attached and removed just like non-fluorous tags and similarly protect functional groups. While attached to your molecule, the fluorous tag also allows for … Continue reading
Posted in F HPLC, Mixture Synthesis
Tagged natural products, petrocortyne, structure elucidation
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In vivo fluorous mixture synthesis
The Hatanaka group has been studying the in vivo glycosylation of fluorous tagged carbohydrates for several years. They have found that various fluorous tagged sugar primers introduced to a culture medium can cross cell membranes, be enzymatically glycosylated, then exit … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Mixture Synthesis
Tagged FMS, FSPE, FTLC, in vivo glycosylation, oligosaccharide
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Fluorous Mixture Sunthesis in Total Synthesis
University of Pittsburgh professor and FTI founder, Dr. Dennis Curran, has extensively used fluorous mixture synthesis (FMS) in natural products chemistry. In their quasiracemic approach, enantiomerically pure starting materials are labeled with a fluorous tag of specific length. For example, … Continue reading
Posted in F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged FMS, natural products, quasiracemic synthesis, tetrafibricin, Total Synthesis
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Fluorous Mixture Synthesis of Dendrimers
In June of last year, the Yu group from the University of Maryland published a report in Angewandte Chemie describing the synthesis of a fluorous dendrimer as a 19F MRI imaging agent. The molecule, dubbed FIT, is pictured below and … Continue reading
Posted in F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged 19F MRI, dendrimers, FIT, FMS
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Synthesis of Resorcylic Acid Lactones
Two interesting Early View papers from Chemistry-A European Journal from Prof. Nicolas Winssinger’s group have recently been published online. Both papers are centered on the synthesis of resorcylic acid lactones. These benzannulated macrolactones have garnered interest due to their inhibitory … Continue reading
Posted in FSPE, Library Synthesis, Mixture Synthesis, Small Molecule Synthesis
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