Category Archives: Library Synthesis

Diversity Oriented Synthesis Using Fluorous Tags

Diversity-oriented synthesis (DOS) has been discussed here often and the benefits of employing fluorous tags and purification methods to the construction of such libraries has been effectively established.  Among these are the solution phase nature of the chemistry, the general … Continue reading

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Tetrahydrofuran Synthesis Using Fluorous Sulfonates.

Prof. Wei Zhang, currently located at UMass-Boston, has been using fluorous aryl sulfonates in library synthesis for some time now.  The fluorous aryl sulfonate can be used as a fluorous tag to facilitate purification of intermediates by fluorous solid phase … Continue reading

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More Diversity-Oriented Synthesis

One of the more contentious topics amongst organic chemists is diversity-oriented synthesis (DOS), the preparation of libraries of chemically diverse molecular scaffolds or ring systems.  Some view it as a critical challenge for chemists and particularly for the pharmaceutical industry … Continue reading

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Combinatorial Libraries: Where to?

The earliest envisioned applications of any technology are not always the ones that end up being the most powerful or popular application.  A good example would be RFID tags, the predecessor of which developed in 1945 in the USSR as … Continue reading

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Cascades, Handovers, and Fluorous Tags

It’s been an year or so since we last saw an publication from Prof. David Procter’s group at the University of Manchester describing their work using fluorous tags.  Previously his group has used fluorous tags in a number of synthetic … Continue reading

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