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Category Archives: Library Synthesis
Parallel Synthesis of O-aryloxyamines
Aryloxyamines are an interesting class of compounds which have been used in a variety of applications. They are excellent intermediates for the synthesis of a number of biologically active heterocycles. They also readily form very stable oximes and have therefore … Continue reading
Linker Strategies in Solid Phase Organic Synthesis
That’s the title of a new book published by Wiley and recently reviewed by Prof. Mark Kurth in J. Am. Chem. Soc. Linker selection is critical to solid phase synthesis since it is the structural element that connects the heterogeneous … Continue reading
Posted in Library Synthesis, Small Molecule Synthesis
Tagged reviews, solid phase synthesis
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Olefin Metathesis and Diels-Alder Reactions
One of the best applications of fluorous tags is in diversity-oriented syntheses (DOS). Since fluorous solid phase extraction (FSPE) is a very general technique, it lends itself well to library and parallel synthesis since there is little method development necessary. … Continue reading
Posted in FSPE, Library Synthesis, Separation Techniques, Small Molecule Synthesis
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CO2 and Mitsunobu Conditions
An Org. Letters ASAP paper from the Merck Research Labs in Boston reports the formation of ureas and carbamates using CO2. The researchers reacted amines and anilines with CO2 catalyzed by DBU to form a carbamic acid intermediate. This intermediate … Continue reading
Posted in Library Synthesis, Scavengers and Reagents, Small Molecule Synthesis
Tagged carbamates, Merck, Mitsunobu, ureas
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Tagging vs. Scavenging vs. Nothing
One of the grants from NIH that we have secured at FTI is a Pilot-Scale Libraries grant for the production and depositing of compounds into NIH’s screening collection, the Molecular Libraries Small Molecules Repository (MLSMR). The MLSMR is part of … Continue reading
Posted in FSPE, Library Synthesis, Scavengers and Reagents, Small Molecule Synthesis
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