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Category Archives: Biomolecule Synthesis
Carbohydrate Research in Action
We’ve published quite a number of posts in F-Blog regarding the synthesis and purification of oligosaccharides using fluorous methods. The justification for the development of many synthetic methods, including fluorous carbohydrate synthesis, is that the molecules produced can then be … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Life Science Applications
Tagged Leishmania, oligosaccharide, tuberculosis
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Synthetic Oligonucleotide Purification by Polymerization
An ASAP Organic Letters paper from Fang and Fueangfung at Michigan Technological University describes their work in using phase tags for the purification of synthetic oligonucleotides. In this case the phase tag is a polymerizable tag attached to the terminal … Continue reading
Fluorinated Amino Acids Probe Peptide-Membrane Interactions
In a recent Biochemistry article, the Marsh group at the University of Michigan continues their work with fluorinated antimicrobial peptides (doi: 10.1021/bi100605e). Though these fluorines are not used in fluorous separations, we’ve enjoyed following the group’s work here in F-Blog … Continue reading
Posted in Assorted Fluorous Items, Peptides
Tagged 19F NMR, antimicrobial peptides (AMP)
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In vivo fluorous mixture synthesis
The Hatanaka group has been studying the in vivo glycosylation of fluorous tagged carbohydrates for several years. They have found that various fluorous tagged sugar primers introduced to a culture medium can cross cell membranes, be enzymatically glycosylated, then exit … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Mixture Synthesis
Tagged FMS, FSPE, FTLC, in vivo glycosylation, oligosaccharide
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Fluorinated Amino Acid Synthesis
The use of fluorinated amino acids to modulate peptide and protein structure has become more prevalent in recent years. The replacement of hydrophobic amino acid residues with fluorous amino acids has provided peptides with clear differences to the native peptide … Continue reading
Posted in Biomolecule Synthesis, Peptides
Tagged fluorous amino acids, hexafluoroleucine
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