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Category Archives: F HPLC
Orthogonal Fluorous Mixture Synthesis (FMS)
University of Pittsburgh Professor and Fluorous Technologies, Inc. founder, Dennis Curran, has over the last several years dedicated a good portion of his research to fluorous mixture synthesis (FMS). In FMS, libraries or isomers of compounds can be made in … Continue reading
Posted in Assorted Fluorous Items, F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged Curran, FHPLC, FMS, macrosphelides
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NMR Analysis of Natural Products with Multiple Stereocenters
Over the last several years, Prof. Dennis Curran’s group has been synthesizing various natural products with multiple stereocenters using fluorous mixture synthesis (FMS). Many of these natural products have been ones with stereocenters distal from each other. What Prof. Curran … Continue reading
Posted in F HPLC, Mixture Synthesis, Small Molecule Synthesis
Tagged Curran, FHPLC, FMS, Total Synthesis
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Fluorous Swern Reaction
The Swern reaction is a very mild and selective method for the oxidation of alcohols to aldehydes and ketones, but suffers from the formation of volatile malodorous dimethyl sulfide. Just about anyone who has spent time in a synthetic chemistry … Continue reading
Posted in Assorted Fluorous Items, F HPLC, Liquid-Liquid Extraction (LLE), Separation Techniques, Small Molecule Synthesis
Tagged Crich, F-DMSO, FLLE, FSPE, Swern oxidation
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Fluorous Mixture Synthesis of Cucurbitosides
In 2008 the Takeuchi group at Niigata University reported the total synthesis of cucurbitoside A, one of a series partially acylated phenolic glycosides. The cucurbitosides are found in the seeds of squashes and pumpkins of the genus Cucurbita. Water extracts … Continue reading
Posted in Assorted Fluorous Items, Carbohydrates, F HPLC, Separation Techniques
Tagged FHPLC, FMS, FSPE, oligosaccharide, Takeuchi
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