Topics
Keywords
ACS ACS meeting asymmetric Biphasic biphasic catalysis carbohydrate Carbohydrates Catalysis combinatorial chemistry Diversity Oriented Synthesis DOS enrichment Events F-Blog FLLE FMS FSPE ISoFT '07 ISoFT'09 Isotope chemistry libraries Library Synthesis Materials Microarray microarray slides Microwave Multicomponent Reactions natural products newsletter NIMS olefin metathesis Oligonucleotides oligosaccharide organocatalyst phase vanishing Proteomics Quality Control review samarium Sigma Aldrich surfactant Thermomorphic Total Synthesis Triphasic User Interview
Category Archives: F HPLC
Encode Information to your Molecules with Fluorous Tags
Fluorous tags, like the amine protecting group F17 Boc-ON, provide a lot of functions. They can be attached and removed just like non-fluorous tags and similarly protect functional groups. While attached to your molecule, the fluorous tag also allows for … Continue reading
Posted in F HPLC, Mixture Synthesis
Tagged natural products, petrocortyne, structure elucidation
Comments Off
Fluorous Mixture Sunthesis in Total Synthesis
University of Pittsburgh professor and FTI founder, Dr. Dennis Curran, has extensively used fluorous mixture synthesis (FMS) in natural products chemistry. In their quasiracemic approach, enantiomerically pure starting materials are labeled with a fluorous tag of specific length. For example, … Continue reading
Posted in F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged FMS, natural products, quasiracemic synthesis, tetrafibricin, Total Synthesis
Comments Off
Fluorous Mixture Synthesis of Dendrimers
In June of last year, the Yu group from the University of Maryland published a report in Angewandte Chemie describing the synthesis of a fluorous dendrimer as a 19F MRI imaging agent. The molecule, dubbed FIT, is pictured below and … Continue reading
Posted in F HPLC, Mixture Synthesis, Separation Techniques, Small Molecule Synthesis
Tagged 19F MRI, dendrimers, FIT, FMS
Comments Off
Fluorous HPLC Separation of Fluorinated Compounds
Prof. Bruce Yu and Nu Xiao at the University of Maryland have just published a paper comparing reverse phase HPLC and fluorous phase high performance liquid chromatography (F-HPLC) for the separation of fluorinated compounds. Note that we do not say … Continue reading
FIT for MRI
As just about everyone knows, magnetic resonance imaging (MRI) is a very important diagnostic technique in medicine. 1H MRI, or NMR as we chemists know it, is the technique used clinically and is a noninvasive technique which provides in vivo … Continue reading
Posted in F HPLC, Separation Techniques, Small Molecule Synthesis
Tagged 19F MRI, Isotope chemistry
Comments Off