Category Archives: F HPLC

Orthogonal Fluorous Mixture Synthesis (FMS)

University of Pittsburgh Professor and Fluorous Technologies, Inc. founder, Dennis Curran, has over the last several years dedicated a good portion of his research to fluorous mixture synthesis (FMS).  In FMS, libraries or isomers of compounds can be made in … Continue reading

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NMR Analysis of Natural Products with Multiple Stereocenters

Over the last several years, Prof. Dennis Curran’s group has been synthesizing various natural products with multiple stereocenters using fluorous mixture synthesis (FMS).  Many of these natural products have been ones with stereocenters distal from each other.  What Prof. Curran … Continue reading

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Fluorous Swern Reaction

The Swern reaction is a very mild and selective method for the oxidation of alcohols to aldehydes and ketones, but suffers from the formation of volatile malodorous dimethyl sulfide.  Just about anyone who has spent time in a synthetic chemistry … Continue reading

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Fluorous Mixture Synthesis of Cucurbitosides

In 2008 the Takeuchi group at Niigata University reported the total synthesis of cucurbitoside A, one of a series partially acylated phenolic glycosides.  The cucurbitosides are found in the seeds of squashes and pumpkins of the genus Cucurbita.  Water extracts … Continue reading

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Fluorous Derivatization for Analysis of Biogenic Amines

Researchers at Fukuoka University have been employing fluorous derivatization extensively for the detection and analysis of specific classes of compounds from biological samples.  To date they’ve used several techniques including tagging and scavenging and enriched samples in targeted analytes from … Continue reading

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