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Category Archives: Carbohydrates
Carbohydrate Research in Action
We’ve published quite a number of posts in F-Blog regarding the synthesis and purification of oligosaccharides using fluorous methods. The justification for the development of many synthetic methods, including fluorous carbohydrate synthesis, is that the molecules produced can then be … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Life Science Applications
Tagged Leishmania, oligosaccharide, tuberculosis
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In vivo fluorous mixture synthesis
The Hatanaka group has been studying the in vivo glycosylation of fluorous tagged carbohydrates for several years. They have found that various fluorous tagged sugar primers introduced to a culture medium can cross cell membranes, be enzymatically glycosylated, then exit … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Mixture Synthesis
Tagged FMS, FSPE, FTLC, in vivo glycosylation, oligosaccharide
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In vivo glycosylation and FSPE
One of the post-ISoFT ’09 F-Blog posts discussed some of the work presented by Prof. Kenichi Hatanaka describing his group’s work in the in vivo glycosylation of fluorous tagged saccharide primers. You can read that post here. Late last year, … Continue reading
Oligosaccharide Catch and Release
The synthesis of oligosaccharides is not easy when compared to to other oligomeric biomolecules such as oligonucleotides and peptides. There’s a number of reasons for this, but primarily it comes down to one thing: complexity. For example, DNA is made … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, FSPE, Separation Techniques
Tagged Carbohydrates, catch and release, FSPE, hydrazine
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H1N1, Carbohydrates, and Microarrays
The study of carbohydrates is of great interest since they are one of the most abundant of cell surface molecules and are, therefore, important players in many intercellular interactions. An example from current events which illustrates the role of carbohydrates … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Life Science Applications, Microarray
Tagged Microarray, NIMS, oligosaccharide, SPR
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