Category Archives: Carbohydrates

Automated Synthesis of Oligosaccharides

The automated synthesis of oligosachharides is a topic that we’ve devoted quite a bit of time on here at F-Blog.  This is largely due to the efforts of Prof. Nicola Pohl’s group who have pioneered the use of fluorous tags … Continue reading

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PTFE Immobilization of Fluorous Tagged Oligosaccharides

A very interesting paper with Prof. Mamoru Mizuno as the corresponding author is now available as an accepted manuscript in Bioorganic & Medicinal Chemistry Letters.  The work presented is the recognition of influenza virus by oligosaccharides immobilized on a polytetrafluoroethylene … Continue reading

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Fluorous Protecting Groups in Oligosaccharide Synthesis

The regular reader of F-Blog will know that the fluorous-assisted synthesis of oligosaccharides is one of the best applications of fluorous techniques.  Fluorous tags and separations, primarily fluorous solid phase extraction (FSPE), have been used in a number of different … Continue reading

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Fluorous Mixture Synthesis of Cucurbitosides

In 2008 the Takeuchi group at Niigata University reported the total synthesis of cucurbitoside A, one of a series partially acylated phenolic glycosides.  The cucurbitosides are found in the seeds of squashes and pumpkins of the genus Cucurbita.  Water extracts … Continue reading

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Reverse Orthogonal Oligosaccharide Synthesis

A just published Advance Article in Chemical Communications from Prof. Alexei Demchenko at the Univ of Missouri-St. Louis describes a strategy for oligosaccharide construction using what they term a reverse orthogonal strategy.  As we have noted here in F-Blog, and … Continue reading

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