Category Archives: Oligonucleotides

ISoFT ’09, Tuesday Report

Posted on August 26, 2009 by Marv

Today was the big day for ISoFT’09 with lectures starting at 8 AM and lasting until 5 PM.  In total there was 18 talks with topics ranging from small molecule chemistry, materials, oligonucleotides, carbohydrates, sensors, and carbohydrates.  With that many … Continue reading →

Posted in Biomolecule Synthesis, Carbohydrates, Life Science Applications, Oligonucleotides, Separation Techniques, Small Molecule Synthesis | Tagged , , , , , | 3 Comments

2009 Berry & Associates catalog

Posted on July 6, 2009 by Marv

Fluorous techniques have been used by numerous research groups in the synthesis and purification of oligonucleotides with impressive results particularly with long oligos consisting of >50 nucleotides. FTI’s partner in oligonucleotide chemistry is Berry & Associates who have developed a … Continue reading →

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Latest Review on Fluorous Chemistry

Posted on January 15, 2009 by Marv

Just available online is a new review from Prof. Wei Zhang of UMass-Boston detailing the use of fluorous tags in synthesis.  The title of the review is “Fluorous Linker-Facilitated Chemical Synthesis” and convers the use of fluorous tags in small … Continue reading →

Posted in Biomolecule Synthesis, Carbohydrates, Oligonucleotides, Peptides, Small Molecule Synthesis | Tagged | Comments Off

Fluorous reagents for oligonucleotide synthesis and purification

Posted on November 25, 2008 by Marv

It’s been awhile since we’ve discussed oligonucleotide synthesis here on F-Blog and it’s probably about time. Several groups have published papers on oligonucleotide synthesis using fluorous tags including Beller and Bannwarth (Helv. Chim. Acta, 2005, 88, 171), Tripathi et al … Continue reading →

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Oligonucleotide Synthesis by Fluorous Capping

Posted on September 5, 2008 by Marv

A US patent application (US2008/0161548 A1) has recently become public describing the use of fluorous capping in solid phase oligonucleotide synthesis. Traditional oligonucleotide synthesis consists of four iterative steps; deprotection of the 5′-OH group, coupling of a nucleotide with the … Continue reading →

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