Category Archives: Oligonucleotides

Fluorous Surrogates for Methylated DNA

One of the most active areas of research in biology and chemical biology is in epigenetics which is the study of changes in gene expression through mechanisms other than a change in the gene sequence.  These can occur either through … Continue reading

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Fluorous Tags and Mass Spectroscopy

The Liu group at the University of North Carolina has been using fluorous tags in the chemoenzymatic synthesis of heparan sulfate, an important oligosaccharide which has been implicated in a variety of biological processes.  The function and effect of heparan … Continue reading

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Highlight on Fluorous Phosphoramidites for Oligonucleotide Purification

Our latest Fluorous Technical Newsletter launched today.  It highlights recent work involving fluorous techniques for oligonucleotide chemistry. To complement the newsletter, we have also updated our page on fluorous phosphoramidites for oligonucleotide synthesis and purification to include links to fluorous … Continue reading

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Synthetic Oligonucleotide Purification by Polymerization

An ASAP Organic Letters paper from Fang and Fueangfung at Michigan Technological University describes their work in using phase tags for the purification of synthetic oligonucleotides.  In this case the phase tag is a polymerizable tag attached to the terminal … Continue reading

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DNA Detection Using Gold Nanoparticles and Fluorous tags

A very interesting Angewandte Chemie Int. Ed. Early View paper from Prof. Jin Zhu at Nanjing University is now available online that describes the use of gold nanoparticles (AuNPs) and fluorous tags for DNA detection.  The researchers have developed a … Continue reading

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