Category Archives: Proteomics

Isotope-coded Fluorous PALs

Prof. Qisheng Zhang at UNC-Chapel Hill has published several papers about the synthesis and use of fluorous tagged photoaffinity labels (PALs) and has just published another report in Chemical Communications.  The general strategy is to attach a photosensitive reactive group … Continue reading

Posted in Life Science Applications, Proteomics | Tagged , , , | Comments Off

Biomolecule Labeling: Fluorous Luminescence

The labeling of biomolecules with exogenous reagents is generally done for one of two purposes either enrichment or detection.  Enrichment labeling is generally in the form of some sort of affinity tag such as biotin, a His tag, and yes, … Continue reading

Posted in Life Science Applications, Proteomics | Tagged , , , | Comments Off

Fluorous Photoaffinity Labeling

Photoaffinity labeling reagents is a valuable way by which to study the interactions between two molecular entities.  Often times this is a ligand and it’s receptor.  The strategy is to attach the photolabel to a ligand, incubate with it’s binding … Continue reading

Posted in Life Science Applications, Proteomics | Tagged , , | Comments Off

Fluorous Tags and Mass Spectroscopy

The Liu group at the University of North Carolina has been using fluorous tags in the chemoenzymatic synthesis of heparan sulfate, an important oligosaccharide which has been implicated in a variety of biological processes.  The function and effect of heparan … Continue reading

Posted in Life Science Applications, Metabolomics, Oligonucleotides, Proteomics | Tagged , , , , | Comments Off

Upon Further Review

Over the past month or two several reviews have been published which mention or have fluorous sections within them.  None of these reviews are dedicated to fluorous techniques, but rather to other topics where fluorous methods are just a part. … Continue reading

Posted in Assorted Fluorous Items, Biomolecule Synthesis, Life Science Applications, Microarray, Proteomics, Small Molecule Synthesis | Tagged , , , , | Comments Off