Category Archives: Proteomics

Glycosphingolipid Analysis using Fluorous Tags

Posted on May 4, 2010 by Marv

Glycosphingolipids (GSLs) are an important class of molecules which have been associated with several cellular functions including antigen activity, cell adhesion, and signal transduction.  As the name suggests these molecules consist of a glycan portion and a lipid portion.  Study … Continue reading →

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Fluorous Photoaffinity Labeling

Posted on March 11, 2010 by Marv

Late last year Prof. Qisheng Zhang at the University of North Carolina published a paper describing his group’s efforts at developing fluorous diazirines as photoaffinity labeling reagents.  For more details on Prof. Zhang’s work, you can view the presentation he … Continue reading →

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FLAC-Fluorous Labeling Assisted Capture

Posted on November 20, 2009 by Marv

The enrichment of peptide subsets is an important part of proteomics in order to simplify sample complexity or to target specific posttranslational modifications for study.  A number of ways for enrichment are known mostly based on affinity chromatography with biotin-avidin … Continue reading →

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Photoaffinity Labeling Reagents with Fluorous Tags

Posted on November 6, 2009 by Marv

Photoaffinity labeling is a technique in proteomics by which to identify ligand binding sites in proteins or to study protein:protein interactions.  The label generally consists of three parts; a) a protein recognition or functional group reactive portion, b) a photoactive … Continue reading →

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Summer Reading

Posted on June 19, 2009 by Marv

With summer here, everyone is looking to add some new titles to their summer reading list.  For me, anything by one of my three favorite authors, Larry McMurtry, Tom Robbins, or Carl Hiaasen is a light, entertaining read. If you’re … Continue reading →

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