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Category Archives: Life Science Applications
Glycosidase Inhibitors and Fluorous Tags
The use of fluorine to modulate physical and biological properties of molecules is well established in drug discovery, either for therapeutics or diagnostics. Usually this means a single fluorine substitution or a trifluoromethyl for a methyl group. Occasionally, one might … Continue reading
Posted in Life Science Applications
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Carbohydrate Research in Action
We’ve published quite a number of posts in F-Blog regarding the synthesis and purification of oligosaccharides using fluorous methods. The justification for the development of many synthetic methods, including fluorous carbohydrate synthesis, is that the molecules produced can then be … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Life Science Applications
Tagged Leishmania, oligosaccharide, tuberculosis
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Glycosphingolipid Analysis using Fluorous Tags
Glycosphingolipids (GSLs) are an important class of molecules which have been associated with several cellular functions including antigen activity, cell adhesion, and signal transduction. As the name suggests these molecules consist of a glycan portion and a lipid portion. Study … Continue reading
Posted in FSPE, Life Science Applications, Microarray, Proteomics
Tagged glycomics, glycosphingolipids, mass spec, Microarray
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Fluorous Photoaffinity Labeling
Late last year Prof. Qisheng Zhang at the University of North Carolina published a paper describing his group’s efforts at developing fluorous diazirines as photoaffinity labeling reagents. For more details on Prof. Zhang’s work, you can view the presentation he … Continue reading
Posted in FSPE, Life Science Applications, Proteomics, Separation Techniques
Tagged cross-linking, Grond, photoaffinity, Proteomics
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H1N1, Carbohydrates, and Microarrays
The study of carbohydrates is of great interest since they are one of the most abundant of cell surface molecules and are, therefore, important players in many intercellular interactions. An example from current events which illustrates the role of carbohydrates … Continue reading
Posted in Biomolecule Synthesis, Carbohydrates, Life Science Applications, Microarray
Tagged Microarray, NIMS, oligosaccharide, SPR
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