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Category Archives: Small Molecule Synthesis
Efforts Toward the Synthesis of Ecteinascidin 597 by Pummerer Cyclization
Prof. David Procter’s group at the University of Manchester have used fluorous thiols in the syntheses of a number of different molecular classes. In each of these cases the goal of the research was to develop methods by which to … Continue reading
Posted in Small Molecule Synthesis
Tagged ecteinascidin 597, Proctor, Pummerer, Total Synthesis
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Fluorous Chemistry in Microfluidics
A just published critical review in Chem. Soc. Rev. from Noël and Buchwald is entitled “Cross-coupling in flow” and highlights metal catalyzed cross coupling reactions in microfluidics. As the authors note, most cross-coupling reactions have been run primarily in batch … Continue reading
Posted in Assorted Fluorous Items, Small Molecule Synthesis
Tagged carbohydrate, microfluidic, Suzuki-Miyaura coupling
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Fluorous Germyl-Stille Coupling
Researchers at Imperial College led by Prof. Alan Spivey have over the last several years been developing methodology using fluorous tagged germanes in metal catalyzed coupling reactions. They’ve found that these germanium compounds can be used in transformations analogous to … Continue reading
Posted in Assorted Fluorous Items, Small Molecule Synthesis
Tagged FSPE, germanium, Spivey, Stille, Total Synthesis
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Combinatorial Libraries: Where to?
The earliest envisioned applications of any technology are not always the ones that end up being the most powerful or popular application. A good example would be RFID tags, the predecessor of which developed in 1945 in the USSR as … Continue reading
Posted in Assorted Fluorous Items, Library Synthesis, Small Molecule Synthesis
Tagged combinatorial chemistry, Diversity Oriented Synthesis, Kodadek
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Fluorous Organocatalyzed Michael Addition
The number of fluorous organocatalysts and the number of reactions they catalyze is getting larger all the time. The marriage of fluorous methods with organocatalysis is particularly attractive since organocatalysts can be costly and may require higher loading compared to … Continue reading
Posted in Small Molecule Synthesis
Tagged Michael addition, Miura, organocatalyst, Thermomorphic
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