Category Archives: Small Molecule Synthesis

Visual Monitoring of Fluorous Solid Phase Extraction (FSPE)

The fluorous solid-phase extraction (FSPE) process is a very robust and  general process.  It’s utility and applicability have been demonstrated over a range of substrates and molecular classes.  One of the great things is the ease of operation.  One wash … Continue reading

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Orthogonal Fluorous Mixture Synthesis (FMS)

University of Pittsburgh Professor and Fluorous Technologies, Inc. founder, Dennis Curran, has over the last several years dedicated a good portion of his research to fluorous mixture synthesis (FMS).  In FMS, libraries or isomers of compounds can be made in … Continue reading

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Fluorous Organocatalyst for Aldol Reactions

Researchers at Gifu Pharmaceutical University led by Prof. Tsuyoshi Miura have been working on fluorous sulfonamide organocatalysts for some time now and have reported their results in various reactions.  These include asymmetric aldol reactions and Michael additions which we have … Continue reading

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Diversity Oriented Synthesis Using Fluorous Tags

Diversity-oriented synthesis (DOS) has been discussed here often and the benefits of employing fluorous tags and purification methods to the construction of such libraries has been effectively established.  Among these are the solution phase nature of the chemistry, the general … Continue reading

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Tetrahydrofuran Synthesis Using Fluorous Sulfonates.

Prof. Wei Zhang, currently located at UMass-Boston, has been using fluorous aryl sulfonates in library synthesis for some time now.  The fluorous aryl sulfonate can be used as a fluorous tag to facilitate purification of intermediates by fluorous solid phase … Continue reading

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