Category Archives: FSPE

Diversity Oriented Synthesis Using Fluorous Tags

Diversity-oriented synthesis (DOS) has been discussed here often and the benefits of employing fluorous tags and purification methods to the construction of such libraries has been effectively established.  Among these are the solution phase nature of the chemistry, the general … Continue reading

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Tetrahydrofuran Synthesis Using Fluorous Sulfonates.

Prof. Wei Zhang, currently located at UMass-Boston, has been using fluorous aryl sulfonates in library synthesis for some time now.  The fluorous aryl sulfonate can be used as a fluorous tag to facilitate purification of intermediates by fluorous solid phase … Continue reading

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18F Radiolabeled Compounds Using Fluorous and Click Chemistry

About one year ago Prof. Veronique Gouverneur described the synthesis of a 18F substituted azide which they used in Staudinger ligations to form 18F containing amides which could be used in PET imaging.  Prior to that they have used the … Continue reading

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Fluorous Protecting Groups in Oligosaccharide Synthesis

The regular reader of F-Blog will know that the fluorous-assisted synthesis of oligosaccharides is one of the best applications of fluorous techniques.  Fluorous tags and separations, primarily fluorous solid phase extraction (FSPE), have been used in a number of different … Continue reading

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Cascades, Handovers, and Fluorous Tags

It’s been an year or so since we last saw an publication from Prof. David Procter’s group at the University of Manchester describing their work using fluorous tags.  Previously his group has used fluorous tags in a number of synthetic … Continue reading

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