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Author Archives: Bru
Perfluoroalkane-tagged chiral auxiliary – application to stereoselective synthesis of a beta-amino acid building block
The advantage of tagging organic compounds or biomolecules with perfluoroalkane groups has led to the publication of several research articles by many. Extending this to the chiral auxillaries is no exception. Several such fluorous oxazolidinone based chiral auxillaries have been … Continue reading
Fluorescence tagging using fluorous-trap fluorogenic reagents
Fluorescent labelling of bioactive materials or other chemicals is a pretty straight forward technique. However, the removal of excess fluorescent reagent from the product is often found to be challenging especially when dealing with highly sensitive detection of analytes. When the … Continue reading
Posted in FSPE, Life Science Applications, Proteomics, Separation Techniques
Tagged analytical chemistry, fluorescence, FSPE, Proteomics
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Thermomorphic perfluoroalkylated-pyridines catalyzing aldol condensation
Aldol condensation is one of the most fundamental and important carbon-carbon bond-forming reactions wherein an enolate ion reacts with a carbonyl compound to form a beta-hydroxyaldehyde or beta-hydroxyketone which upon dehydration results in a conjugated enone. The reactions are usually … Continue reading
Fluorous surfactants as new spermicidal contraceptives?
Of late, fluorous surfactants (detergents) have been increasingly making their way into various biomedical and pharmaceutical applications. Another new addition to this family is a recent patent (WO2009/026375) filed by Lehigh University that describes the spermicidal and microbicidal properties of fluorous … Continue reading
Are fluorinated surfactants less cytotoxic?
As per a recent communication (New J. Chem., 2008, 32, 2169), this indeed appears to be the case, at least for single-tailed glucopyranoside surfactants compared to their hydrocarbon counterparts. Non-ionic surfactants of this type are of interest in biomedical applications, … Continue reading
Posted in Assorted Fluorous Items
Tagged drug delivery, Materials, surfactant, toxocity
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