F-CDMT is a fluorous version of CDMT (2-chloro-4,6-dimethoxy-1,3,5-trazine) that has been extensively used as a coupling agent to form amines. CDMT is known to give good to high yields of coupling products between sterically hindered substrates. F-CDMT reacts analogously to CDMT with the added benefit that the triazone byproduct of the reaction can be readily removed either by F-SPE or fluorous liquid-liquid extraction. The formation of small peptides using F-CDMT has been reported (1) as has the use of F-CDMT in amide bond formation with plate-to-plate F-SPE using a 24 well plate (2).
1. Markowicz, M. W.; Dembinski, R. Synthesis, 2004, 80-86.
2. Zhang, W.; Lu, Y.; Nagashima, T. J. Comb. Chem. 2005, 7, 893-897.