Home
 
 
Peptide reagents + amino acids

Click on links below to change displayed product
 

Fmoc

Boc-ON

F-Z-Osu

Trityl chlorides

Trityl alcohols

CDMT

t-Butanol

Mukaiyama's Reagent

HOBt

Msc chloride   

DCC

Fmoc & Boc-protected amino acids

Z-protected amino acids

  

2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT)
 

 

F-CDMT is a fluorous version of CDMT (2-chloro-4,6-dimethoxy-1,3,5-trazine) that has been extensively used as a coupling agent to form amines.  CDMT is known to give good to high yields of coupling products between sterically hindered substrates.  F-CDMT reacts analogously to CDMT with the added benefit that the triazone byproduct of the reaction can be readily removed either by F-SPE or fluorous liquid-liquid extraction.  The formation of small peptides using F-CDMT has been reported (1) as has the use of F-CDMT in amide bond formation with plate-to-plate F-SPE using a 24 well plate (2).

 

1. Markowicz, M. W.; Dembinski, R. Synthesis, 2004, 80-86.

2. Zhang, W.; Lu, Y.; Nagashima, T. J. Comb. Chem. 2005, 7, 893-897.

 

Rf NAME/CAS# PROPERTIES CATALOG# QTY PRICE
C6F13 2-chloro-4,6-di(perfluorohexyl)propyloxy-1,3,5-triazine (F-CDMT)  
C21H12ClF26N3O2
F026171-0002 2g Inquire
    FW:  867.78 F026171-0010 10g Inquire
      F026171-0025 25g Inquire
      F026171-0100 100g Inquire
     
C8F17 2-chloro-4,6-di(perfluorooctyl)propyloxy-1,3,5-triazine (F-CDMT)  
C25H12ClF34N3O2
F034171 Please Inquire for Pricing & Availability
    FW:  1067.82