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Peptide reagents + amino acids

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Fmoc

Boc-ON

F-Z-Osu

Trityl chlorides

Trityl alcohols

CDMT

t-Butanol

Mukaiyama's Reagent

HOBt

Msc chloride   

DCC

Fmoc & Boc-protected amino acids

Z-protected amino acids

  

Mukaiyama's Reagent
 

 

F-Pyridinium salt is the fluorous analog to 2-halopyridinium salts that have been widely used for the activation of carboxylic acids to form esters, amides, and lactones.  Pyridinium salts are efficient coupling reagents for peptide synthesis and exhibit faster formation of coupling products than other commonly used coupling reagents including BOP-Cl, PyBroP, and PyClU.  The fluorous version is especially useful with HOBt to rapidly form activated acid as the corresponding benzotriazoyl ester (1).  The pyridone by product is easily removed from the desired product by F-SPE.

 

1. Nagashima, T.; Lu, Y.; Petro, M. J.; Zhang, W. Tetrahedron Lett. 2005, 46, 6585-6588.

2. Matsugi, M., Hasegawa, M., Sadachika, D., Okamoto, S., Tomioka, M., Ikeya, Y., Masuyama, A., Mori, Y., Tetrahedron Letters 2007, DOI: 10.1016/j.tetlet.2007.03.173

 

Rf NAME/CAS# PROPERTIES CATALOG# QTY PRICE

2-chloro-1-(1H,1H,2H,2H-perfluorodecyl)pyridinium triflate

(F-Mukaiyama's Reagent)

C16H8ClF20NO3S
F017255-0002 2g Inquire
    FW:  709.74 F017255-0010 10g Inquire