Fluorous isocyanate is a solution-phase scavenger of nucleophiles such as amines and thiols and has been used in the solution phase parallel synthesis of urea, thiourea, and β-hydroxyamine analogs (1,2,3). F017032, the C8F17 analog, has appropriate fluorine content for the tagging of diverse organic molecules and is recommended for natural product or medicinal chemistry synthesis in combination with fluorous solid phase extraction. For the use of fluorous isocyanate in the tagging and enrichment of peptides in proteomics applications, please see the Bioreagents section.
1. Zhang, W.; Chen, C. H.-T.; Nagashima, T. Tetrahedron Lett. 2003, 44, 2065-2068.
2. Zhang, A. S.; Elmore, C. S.; Egan, M. A.; Melillo, D. G.; Dean, D. C. J. Labeled Compounds & Radiopharmaceuticals 2005, 48, 203-208.
3. Lindsley, C. W.; Zhao, Z.; Leister, W. H. Tetrahedron Lett. 2002, 43, 4225-4228.