Home
 
 
Protecting groups and tags

Click on links below to change displayed product

Boc-ON  

Silanes

PMB OH

t-Butanol   

Cbz-Osu  

Thiol   

Benzyl alcohol

FluoMar  

Oxybenzaldehyde

Fmoc  

Trityl Chlorides

Trityl Alcohols

Thiophenol

Fluorous tags are perfluoroalkyl modified versions of traditional protecting groups familiar to synthetic organic chemists.  Conceptually they are very similar to solid phase tags, but fluorous tags and fluorous tagged substrates are soluble in most organic solvents, such as DMF, THF, CH2Cl2, etc.  This provides some distinct advantages over solid phase tagging strategies including solution phase kinetics, complete control of reaction stoichiometry, and the ability to monitor reactions easily using traditional analytical techniques, including TLC, NMR, GC, LC/MS, and IR.  The fluorous tagged materials are easily separated from non-tagged components by F-SPE.  Fluorous tags have been used in a variety of total, parallel, and mixture syntheses (1-3).

1. Zhang, W. “Fluorous Protecting Groups and Tags” in Handbook of Fluorous Chemistry Gladysz, J. A.; Curran, D. P.; Horvath, I. T. Eds. Wiley-VCH, 2004, pp222-2362.

2. Zhang, W. “Fluorous Tagging Strategy for Solution-Phase Synthesis of Small Molecules, Peptides and Oligosaccharides” Curr. Opin. Drug Disov. Develop. 2004, 7, 784-797.

3. Curran, D. P. In Stimulating Concepts in Chemistry; Stoddard, F., Reinhoudt, D., Shibasaki, M., Eds.; Wiley-VCH: New York, 2000, p 25-37.

 
 
t-Butanol
Rf NAME/CAS# PROPERTIES CATALOG# QTY PRICE
C3F7 2-Methyl-4-perfluoropropyl-2-butanol  
C8H11F7O
F007007-0002 2g Inquire
    FW:  256.19 F007007-0010 10g Inquire
      F007007-0025 25g Inquire
      F007007-0100 100g Inquire
     
C4F9 2-Methyl-4-perfluorobutyl-2-butanol
269394-08-3
C9H11F9O
F009007-0002 2g Inquire
    FW:  306.2 F009007-0010 10g Inquire
      F009007-0025 25g Inquire
      F009007-0100 100g Inquire
     
C6F13 2-Methyl-4-perfluorohexyl-2-butanol
159142-65-1
C11H11F13O
F013007-0002 2g Inquire
    FW:  406.22 F013007-0010 10g Inquire
      F013007-0025 25g Inquire
      F013007-0100 100g Inquire
     
(CF2)4CF(CF3)2 2-Methyl-4-(perfluoro-5-methylhexyl)-2-butanol  
C12H11F15O
F015007-0002 2g Inquire
    FW:  456.23 F015007-0010 10g Inquire
      F015007-0025 25g Inquire
      F015007-0100 100g Inquire
     
C8F17 2-Methyl-4-perfluorooctyl-2-butanol
141183-94-0
C13H11F17O
F017007-0002 2g Inquire
    FW:  506.22 F017007-0010 10g Inquire
      F017007-0025 25g Inquire
      F017007-0100 100g Inquire
     
(CF2)6CF(CF3)2 2-Methyl-4-(perfluoro-7-methyloctyl)-2-butanol  
C14H11F19O
F019007-0002 2g Inquire
    FW:  556.25 F019007-0010 10g Inquire
      F019007-0025 25g Inquire
      F019007-0100 100g Inquire
     
C10F21 2-Methyl-4-perfluorodecyl-2-butanol  
C15H11F21O
F021007-0002 2g Inquire
    FW:  606.26 F021007-0010 10g Inquire
      F021007-0025 25g Inquire
      F021007-0100 100g Inquire